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Molecular mechanisms of local anaesthetic action on voltage-gated ion channels
(2004-04-02)
In this thesis I try to clarify some molecular mechanisms of local anaesthetic action on ion channels. The traditional view is that local anaesthetics eliminate action potentials by a direct block of Na channels. Other ...
Bioinformatic methods in protein characterization
(2002-11-08)
Bioinformatics is an emerging interdisciplinary research field in which mathematics. computer science and biology meet. In this thesis. bioinformatic methods for analysis of functional and structural properties among ...
Factors associated with healing of periradicular lesions
(2003-01-24)
Healing of periradicular lesions is a complex process. This thesis addressed some factors of importance to the outcome, namely treatment options and host response in cases of refractory lesions, levels of pro-inflammatory ...
Spinal cord injury : mechanical and molecular aspects
(2002-05-10)
are preceded
by edema.
Functional magnetic resonance imaging (fMRI) is based on observations
that neural activation leads to alter- ations of local cerebral
metabolism, coupled to changes in local cerebral blood flow. We performed
fMRI at 4.7 Tesla...
Studies of presenilin function in neurodegeneration and in human embryonic CNS during development
(2004-05-21)
Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial
Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity
for cleaving transmembrane proteins such as the amyloid precursor ...
Physical activity and fitness among adolescents in Sweden with a 20-year trend perspective
(2003-10-03)
To prevent chronic diseases such as cardiovascular disease and type-2 diabetes, it is important to avoid body fatness, to remain physically active and to maintain aerobic fitness. It is also important to maintain a certain ...
The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and theur relation to the inflammatory process in vivo
(2001-12-28)
In inflammatory reactions, eosinophils and neutrophils constitute the
major classes of granulocytes that emigrate from the bloodstream into the
tissues. The recruitment of inflammatory cells constitutes a multi-step
process ...
Minimally invasive hernia surgery
(2003-04-25)
Lichtenstein (5 vs. 7 days). The time of rehabilitation was shorter after TEP than mesh-plug or Lichtenstein (14 vs. 24.5 vs. 28.5 days). There was a tendency of more pain after Lichtenstein than after TEP or mesh-plug at follow-up. Laparoscopic hernioplasty...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...
Morphological and molecular changes in developing guinea pig osteoarthritis
(2003-01-31)
Osteoarthritis (OA) - an unspecific term for late joint destruction-is one of the most common causes of pain and disability in elderly. OA is characterized by destruction of articular cartilage and insufficient tissue ...