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Molecular cloning and characterization of the murine acyl-CoA thioesterase CTE-I
(2004-04-23)
Mouse cytosolic type I acyl-CoA thioesterase (CTE-I) is a member of the
type I family of acylCoA thioesterases. These enzymes hydrolyze acyl-CoAs
to non-esterified fatty acids (NEFAs) and Coenzyme A (CoA-SH) and are
strongly ...
Allergen-induced airway reactions in the pig in vivo : inflammatory mediators as targets for asthma therapy
(2002-03-01)
A pig model for studies of allergen-induced airway reactions has previously been developed. These pigs are actively sensitized to Ascaris suum and challenged with this antigen in the airways under anesthesia. In the present ...
Endocrine aspects of obesity and weight reduction by bariatric surgery : with special emphasis on beta cell function
(2003-09-11)
Severe obesity is the most predictive acquired risk factor for the development of type 2 diabetes. Bariatric surgery induces marked weight loss and reverses the diabetic state significantly. This could be explained not ...
Use of affordable technology for the sensitive and specific diagnosis of onchocerciasis (river blindness)
(2002-10-11)
Onchocerciasis or river blindness is the most common infectious cause of
blindness. Even in the absence of blindness, the skin effects caused are
of social stigma. It is the goal of the World Health Organization to
eradicate ...
Targeting HIV-1 entry and reverse transcription by vaccination
(2002-11-13)
Human immunodeficiency virus type I (HIV-1) is a complex retrovirus,
which uses the CD4 receptor and chemokine receptors to infect its target
cells. The chemokine receptor CCR5 is essential for primary HIV-1
infection. The ...
Factors affecting attendance at population-based mammography screening
(2002-01-11)
The aim of the studies described in this thesis was to explore factors affecting attendance at outreach mammography screening, and to assess possible associations between socioeconomic factors and breast cancer ...
Cellular immunity and inflammation in atherosclerosis
(2001-11-09)
Atherosclerosis, the major cause of death and disability in western countries, is nowadays recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the ...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
We have investigated the association of the humoral immune factors
circulating immune complexes (CICs) and autoantibodies against
cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic
vascular diseases.
In ...
Paracrine regulation of Sertoli cell proliferation
(2003-02-14)
with the important endocrine Sertoli cell regulator FSH. Furthermore, the cytokines IL-6 and IFN-gamma modulated the FSH effect in different ways. IL-6 increased, while IFN-gamma inhibited FSH-induced Sertoli cell proliferation. Bacterial endotoxin directly...
Life without thyroid hormone receptors
(2003-08-08)
Thyroid hormone (TH) has many important functions during development and in the adult individual. It reaches its target cells via the blood system and binds its receptor (TR) located within the cell nucleus where the ...