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Molecular mechanisms in amyloid fibril formation
(2004-05-21)
P-peptide (Abeta) is suggested to be responsible for Alzheimer's disease. The aggregation profile of Abeta(1-40) studied by electrospray ionisation (ESI) -MS, shows first order kinetics of Abetaaggregation. During the experiment, acid...
Functional analysis of genetic variants in putative low penetrate breast cancer genes
(2004-09-03)
was detected in one of the familial breast cancer patient with both ductal and lobular foci. Putative breast cancer risk conferred by the promoter polymorphism -161C-A of CDH1 or 1774G-A (Ala592Thr) was also analyzed in case-control studies. No significant...
New evidence on germ-cell testicular cancer aetiology
(2004-01-09)
different points in life on 371 cases and 1,238 controls. We found that height at eighteen years old is directly associated with testicular cancer risk. The association persisted after adjusting for perinatal characteristics, suggesting that both foetal life...
Affective disorders in a stress-vulnerability perspective : a clinical, biological and psycho-social study
(2002-11-15)
of hospitalization during a three-year follow-up had a significantly higher level of harm avoidance, a higher level of interpersonal problems, and a lower level of sense of coherence.
In summary, the results of this thesis suggest that: (1) genetic factors play a...
Modulation of activity of the tumour suppressor p53 by small molecules and damaged DNA
(2004-04-16)
The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p53 triggers a cell cycle arrest in GI or apoptosis, ensuring a suppression of a tumor development by the elimination of ...
Purification, structure and function of bioactive peptides
(2004-04-02)
Peptides are vitally important molecules and many evoke cellular responses. The completion of several genome sequencing projects has revealed a number of new genes. However, as functional peptides often contain posttranslational ...
Women’s expectations and experience of care during pregnancy and childbirth
(2003-10-03)
This thesis focuses on a national sample of Swedish-speaking women’s expectations and experience of antenatal care and women’s opinions of Caesarean section, homebirth and birth centre care. Paper (I): The aim was to ...
Rehabilitation in a changing context : responses, difficulties and competence from the view of occupational therapists and clients : consequences of the ideological and organisational changes in psychiatry
(2003-05-23)
in psychiatric care [the criterion variable] during the reorganization of psychiatry. The data were based on the same questionnaires as in study 1. Stepwise regression analyses revealed that the nature of work was highly related to the criterion variable...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
. Generally, the risk of local recurrence was higher than expected, but the estimated survival rates were gratifying. The overall risk of local recurrence was 9.2% at five years and 21.1% at ten years, and the breast cancer-specific survival was 93.3% and 85...
Subcellular localization and signalling of Brutons tyrosine kinase (Btk)
(2002-11-28)
of cytoskeletal reorganization resulting in membrane ruffle formation.
Moreover, we found that Btk can translocate to the nucleus and that Btk
utilizes functional CRM-1 dependent nuclear export signal(s) to shuffle
between the nucleus and the cytoplasm. We also...