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Organohalogen contaminants in humans with emphasis on polybrominated diphenyl ethers
(2002-02-08)
-10% in liver and 0.03-0.4% in adipose tissue, while the levels of OH-PCBs in breast milk were inconsiderable. Matrix specific differences were observed in OHPCB congener distribution. 2,2',3,4',5,5',6-heptachloro-4-biphenylol (4-OH-CB187) and 2...
Studies of prognostic and functional outcomes in surgery for rectal cancer
(2003-09-26)
resection. Bowel function was evaluated at 6,12 and 24 months with a questionnaire and anorectal physiology was investigated with manometry of the anal sphincter and manovolumetry of the neo-rectum. Although neo-rectal volume was larger in the J...
Genetic dissection of multifactorial disease models in the rat
(2002-08-26)
weight. The first genome-wide scan with 253 markers revealed three glucose-related loci, Niddm I (LOD 11), Niddm2 (LOD 4.5) and Niddm3 (LOD 4.6), and one locus, Weight1 (LOD 6.2), for body weight on chromosomes 1, 2, 10, and 7 respectively, supporting...
Experimental nerve injury : induced pain : mechanisms and modulation
(2004-03-26)
Chronic nerve injury-induced pain presents a therapeutic challenge since
such pain is often resistant to conventional analgesic drugs including
opioids. Better knowledge of the pathophysiological mechanisms underlying
nerve ...
Molecular dynamics studies of water and biomolecules
(2002-05-24)
This thesis concerns different areas of molecular dynamics (MD) simulations. In the first part of the thesis the ability of liquid water models to mimic the real bulk water properties and the accuracy of the methods to ...
Hazardous or harmful alcohol use in emergency care : early detection, motivation to change and brief intervention
(2003-05-21)
Alcohol often leads to accidents, assaults, poor health in the family and is associated with psychiatric and somatic diseases. Binge drinking, in particular, has been shown to be a central factor in alcohol related problems. ...
Cholesterol turnover in acute myelogenous leukemia with special emphasis on regulation of low density lipoprotein receptor expression in leukemic cells
(2001-10-26)
) and IL-4 stimulated LDL receptor activity by up to 150% and caused a decreased sensitivity to sterols in normal cells. The stimulatory effect of AML cell conditioned medium on normal cells was not reversed by neutralizing IL-2, IL-4, IL6, or oncostatin M...
Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis
(2003-11-13)
How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. ...
Intestinal functions in animals : an experimental study on horses, pigs, cows and fish
(2001-11-07)
Animals and humans live in symbiosis with an active gastrointestinal
ecosystem. The balance of the system is maintained by the main actors,
the macroorganism, the microflora and the environment, in concert.
Microflora ...