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Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), ...
Nursing documentation in clinical practice : instrument development and evaluation of a comprehensive intervention programme
(2002-09-27)
The purpose of this study was to describe and analyse effects of a two-year comprehensive intervention concerning nursing documentation in patient records when using the VIPS model - a model designed to structure nursing ...
Life without thyroid hormone receptors
(2003-08-08)
Thyroid hormone (TH) has many important functions during development and in the adult individual. It reaches its target cells via the blood system and binds its receptor (TR) located within the cell nucleus where the ...
Strategies of gene and immune therapy for tumors and viral diseases
(2003-04-04)
In the treatment of tumors and viral diseases such as HIV-1 infection, immunotherapeutic strategies do not seem to have enough capacity to eradicate an already established disease. However, these strategies could play a ...
Telephone advice nursing : callers’ perceptions, nurses’ experience of problems and basis for assessments
(2004-01-02)
At a health care call center, care-seekers can consult telephone nurses 24 hours a day. Telephone advice nursing (TAN) includes triage, advice, support, education, referral, information and coordination. The overall aim ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
Enhancement of HIV-1 DNA immunogens
(2002-11-14)
Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected ...
Intestinal functions in animals : an experimental study on horses, pigs, cows and fish
(2001-11-07)
Animals and humans live in symbiosis with an active gastrointestinal
ecosystem. The balance of the system is maintained by the main actors,
the macroorganism, the microflora and the environment, in concert.
Microflora ...
Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release
(2003-05-23)
Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic ...