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Parasite signalling and host responses in experimental and human African trypanosomiasis
(2002-08-08)
African trypanosomiasis or sleeping sickness is a disease of tropical Africa caused by the unicellular-flagellated protozoan parasite, Trypanosoma brucei (T b.), which is transmitted by its insect vector, the tsetse fly. ...
Structural insights into glycoprotein transport and viral escape
(2004-02-16)
The correct trafficking of proteins through the secretory pathway is essential for the maintenance of cellular functions. Increasing evidence suggests that at least for some glycoproteins, export from the endoplasmic ...
Living with Ehlers-Danlos syndrome
(2003-05-15)
This thesis focuses on how individuals with the Ehlers-Danlos syndrome (EDS), an inherited connective-tissue disorder, experience and describe their daily lives with focus on physical and psychosocial problems. The syndrome ...
Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation
(2003-03-06)
Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression ...
Studies of VEGF-B and novel PDGFs in tumorigenesis and angiogenesis
(2004-02-06)
The family of VEGF/PDGF growth factors and their receptors are important regulators of tumorigenesis and angiogenesis. VEGFs have been shown to play important roles in development of both blood and lymphatic vessels by ...
Effects of bacterial toxins on calcium homeostasis in renal inflammation
(2004-04-23)
-dependent effect where high concentrations caused elevated levels of Ca 2+ followed by cell lysis, whereas sub-lytic concentrations induced intracellular Ca2+ oscillations. Spectral analysis revealed that oscillations occurred with a periodicity of 12.0 ± 0.7 min...
Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures
(2004-03-26)
Skeletal muscle is an insulin sensitive organ and plays a major role in
whole body electrolyte and substrate homeostasis in the post prandial
state. Impaired insulin action in skeletal muscle may lead to the
pathological ...
Megencephaly, significance, biology and identification of a genetic cause
(2002-05-17)
Enlarged brain is termed megencephaly or megalencephaly, and is defined as a brain volume above the 98th percentile. It is a major sign in several neurological diseases with symptoms ranging from very mild to lethal, ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. ...