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Characterization of NPY receptors Y1, Y2 and Y5 expression and function in vivo
(2003-11-25)
with increased food intake and reduced energy expenditure compared to wild type mice.
A possible physiological role for NPY receptors in pain transmission was studied by analysing Y1 and Y2 receptor deficient mice. Y1 receptor mutant mice exhibited increased...
Skin cancer prevention : readiness to change sun-related behaviours
(2004-04-02)
The general aim of this thesis was to collect data relevant for skin
cancer prevention and to investigate the applicability of the
Transtheoretical Model for sun-related behaviour. Also, to assess the
readiness to change ...
Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance
(2004-05-21)
The thioredoxin system, comprising thioredoxin, thioredoxin reductase (TrxR) and NADPH, is a redox system of great importance in the defence against oxidative stress and is involved in the regulation of several cellular ...
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(2004-04-02)
RNA expression and amplification of the multidrug resistance gene (MDR-1). The MDR-1 gene amplification correlated also to the expression levels of the P-glycoprotein. In the doxorubicin resistant U-1285dox900 cells, the resistance correlated with the MRP1 gene...
Individual health, neighborhood characteristics, and allocation of primary health care resources
(2003-08-08)
Aims: To examine whether neighborhood education and neighborhood income predict incidence rates of coronary heart disease (CHD), beyond individual characteristics (study 1); to examine whether neighborhood deprivation, measured with Care Need Index...
Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents
(2002-08-30)
class I tetramers to Ly49A and Ly49C, indicating that both these receptors bind to MHC class I in a similar manner, partly involving the beta2m-subunit.
To investigate the influence of beta2m on the structure of MHC class 1, in particular in relation...
Dendritic cells in immune and gene therapy against cancer
(2003-01-10)
Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid ...
Effects of influenza A virus infections and interferon-gamma on synapse formation and function in hippocampal neurons in culture
(2004-09-03)
strain used in this study has previously been shown to selectively infect the hippocampus and the substantia nigra in mice following intracerebral and systemic injections. In my thesis the following observations were made: 1) Infected hippocampal neurons...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
three times a week (t.i.w.). This difference persisted during the initial 12 weeks for patients infected with genotype 1, but was not maintained from day 14 and onwards for patients infected with genotype non-1. Eighty percent of patients...