Search
Now showing items 1-10 of 49
Studies on genetic hemochromatosis and the hepatotoxicity of iron
(2002-05-17)
The aim of this study was to investigate the mutations and clinical
expression of genetic hemochromatosis in patients and mechanisms involved
in the hepatotoxicity of iron in animal and cell- culture models.
In Swedish ...
Risk and resilience in children born preterm : cognitive and executive functioning at 5 1/2 years of age
(2003-11-28)
g or less (very-low-birthweight: VLBW) and a control group of 125 children born healthy at term who were examined with the Wechsler Preschool and Primary Scale-Revised (WPPSI-R) and a neuropsychological test battery (Nepsy) at 5½ years of age ((paper...
Molecular factors relevant to the radiosensitivity of human tumours
(2003-05-16)
Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC ...
Vector development for suicide gene therapy
(2002-05-03)
-mediated integration in several cultured cell lines as well as
primary human donor T-lymphocytes (Paper IV).
We have prepared suicide gene therapy vectors containing HSV-tk and OuaR
selection marker fusion gene in extensively optimised retroviral backbone
SF91...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Cholangiocarcinoma in primary sclerosing cholangitis
(2001-10-05)
, the kappa level for dysplasia being 0.44. Comparison of the frequency of bile duct dysplasia in livers from patients with PSC with and without CC showed dysplasia in 19% (5/26) of the cancer patients and in 0% (0/60) of non-cancer patients (p<0...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
-99 according to an extensive investigational protocol. A presumptive explanation of the stillbirth was established in 91% of the cases. The most common factors associated with intrauterine fetal death could be identified as infections (24%), placental...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Strategies of gene and immune therapy for tumors and viral diseases
(2003-04-04)
-mediated expression of small interfering RNAs (siRNA) against either endogenous transcripts for the primary HIV-1 coreceptor, CCR5, or viral transcripts for the Rev gene of HIV-1, we were able to inhibit efficiently both viral infection and replication, respectively...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...