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Functional features of human cytochrome P450 1A2 : with special focus on caffeine and melatonin metabolism
(2002-11-15)
CYP1A2 is one of the major cytochrome P450 enzymes in the liver and metabolises drugs such as caffeine, clozapine, tacrine, and theophylline. CYP1A2 also has a role in chemical carcinogenesis due to its activation of procarcinogens...
Survival and differentiation of central noradrenergic neurons
(2002-08-09)
and memory acquisition. The
development of LC noradrenergic neurons is severely affected by
reductions in the availability of BMPs in vivo, and by the lack of the
basic helix-loophelix protein Mash1, or the Phox2a, Phox2b or Rnx
homeodomain proteins, as shown...
Bronchoalveolar lavage and serum protein patterns in healthy individuals and sarcoidosis patients : a proteomics approach
(2004-01-23)
and handling method based on a proteomics approach to
identify specific proteins in the BALF. Normal BALF protein samples were
investigated and the protein contents were mapped in the pH interval
4.5-5.2. Furthermore we analyzed the protein expression changes...
Developmentally supportive neonatal care : a study of the newborn individualized developmental care and assessment program (NIDCAP) in a Swedish environment
(2003-04-04)
A family-centred, developmentally supportive approach to newborn intensive care, referred to as the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) has attracted considerable interest in recent ...
An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors
(2003-01-03)
key findings were elevated risks of EOC among ever users compared with never users of both unopposed estrogens (OR= 1.43, 95% Cl 1.02-2.00), and estrogens supplemented with sequential progestins (OR=1.54, 95% Cl 1.15-2.05), while no excess risk...
Apolipoprotein E and Alzheimer's diseases : signals and effects
(2002-04-26)
Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. ...
Body site of cutaneous malignant melanoma : primary tumor location in relation to phenotypic and prognostic factors
(2002-11-08)
The main purpose of this thesis was to analyze the primary body site of cutaneous malignant melanoma (CMM) in relation to phenotypic traits and prognosis. It is clear that several characteristics of CMM are different, and ...
Extrahepatic cytochrome P450s : relation to cancer susceptibility
(2003-09-19)
against the EST database and the high throughput genomic sequences database. The gene was found to be located together with the genes of subfamily CYP2A, CYP2B and CYP2F on chromosome 19. The predicted 504 amino acid sequence displayed 38-49 percent...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
) on this process, a series of PGs were analyzed by semi quantitative reversed transcriptase polymerase chain reaction. The cells with epithelial phenotype showed increased expression of syndecan-2, syndecan-4 and hyaluronan synthase, and fibroblast-like cells...