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Expression and regulation of vasoactive substances, sex steroids and their receptors in placenta during normal pregnancy and preeclampsia
(2002-04-12)
Despite intense studies preeclampsia remains enigmatic and a major cause of maternal and fetal morbidity and mortality. It is now widely accepted that the placenta has a central role in preeclampsia; delivery of the placenta ...
Molecular and functional studies of interleukin-1a in the rat testis
(2002-11-15)
variant was found and named as 24proIL-1 alpha. It lacked exon 5, which harbors the cleavage site of the processing enzyme calpain. Expression of these isoforms in COS. cells and in vitro calpain cleavage assay of recombinant protein expressed in E. coli...
Isolation and characterization of regulatory peptides and bioactive compounds
(2004-04-28)
Isolation of peptides and other bioactive compounds is an important and often necessary step to get the total information about their structures. This is demonstrated by a number of different characterizations in this ...
Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity
(2002-05-22)
Studies of animal models of type 2 diabetes mellitus implicate that impaired insulin signal transduction to glucose transport accounts for whole body insulin resistance in skeletal muscle and adipose tissue. The overall ...
Effect of pharmacological treatment of serotonergic function in depression
(2002-05-03)
Since its identification in raphe neurons of the central nervous system (CNS), the biogenic amine serotonin (5- hydroxytryptamin, 5-HT) has been implicated in the etiology and pathophysiology of affective disorders, such as depression. It has been...
HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden
(2001-08-08)
Infection with human papillomaviruses (HPV) types 16 and 18 is the major
cause of cervical neoplasia. Although a high proportion of cervical
cancers (CXCA) harbor HPV genomes, only a small number of women infected
with ...
Technology development for genome and polymorphism analysis
(2003-01-24)
Single nucleotide polymorphism (SNP) is widely expected to provide a multitude of benefits in areas of medical research. There is, however, a growing disparity between the rate of SNP discovery and the development of ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
We have investigated the association of the humoral immune factors
circulating immune complexes (CICs) and autoantibodies against
cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic
vascular diseases.
In ...
Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution
(2004-05-14)
A striking characteristic of HIV is the enormous capacity of genetic
variation. Frequent mutations, deletions, insertions and recombination
events create a population of genetically related but non-identical
viruses ...