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The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae
(2003-08-08)
Nontypeable Haemophilus influenzae (NTHi) is an important cause of otitis media and respiratory tract infections. Its lipopolysaccharide (LPS) molecule, an outer membrane component, is a major virulence factor of NTHi. The ...
Expression and regulation of vasoactive substances, sex steroids and their receptors in placenta during normal pregnancy and preeclampsia
(2002-04-12)
in the different groups showed that the level was decreased in severe preeclampsia but increased in mild preeclampsia compared to healthy controls. Measurement of progesterone content in placental tissue explants showed that addition of the antiprogestin RU-486...
Membrane protein topology : prediction, experimental mapping and genome-wide analysis
(2004-05-12)
Membrane proteins constitute a large and important class of proteins.
They are responsible for many crucial processes in living cells, and
about 25% of all proteins encoded by a typical genome are predicted to be
membrane ...
Structure and function of hepatic cytochromes P450 : implications for drug development
(2002-11-25)
6 allele (CYP2D6*17) common in Black African populations
carrying three mutations Thrl07IIe, Arg296Cys and Ser486Thr was
investigated by recombinant expression and the enzyme characterized using
CYP2D6 specific substrates. It was found that both...
Occupational exposure to electromagnetic fields and chronic diseases
(2003-11-21)
This thesis consider two exposures from the electromagnetic spectrum extremely low-frequency magnetic fields (ELF MF) and ultraviolet (UV) radiation. ELF MF are the lowest and UV radiation ranges among the highest frequencies ...
Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring
(2002-04-05)
Aberrant activation of cells of the immune system plays a major role in the pathogenesis of HIV infection. The major aims of the thesis were: (a) to measure the effects of current antiretroviral therapy on immune activation ...
The human antimicrobial peptide hCAP18 in epithelial defense
(2001-11-16)
Gene-encoded antimicrobial peptides serve a protective role in host defense. They are multifunctional effector molecules in innate immunity - the nonadaptive immune system -with the capacity to kill a broad spectrum of ...
Molecular consequences of cellular UDP-glucose deficiency
(2004-05-21)
A Chinese hamster fibroblast mutant cell line, deficient in UDP-glucose (UDPG), denoted as Qc, and its counterpart cell line with normalized levels of UDPG (G3), were used to determine some molecular consequences of chronic ...
Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules
(2003-03-10)
not detected at levels above the detection limit, 0.3 ng/g wet brain, while pregnenolone sulphate, added to brain extract at a level of 6.6 ng/g, was easily detected. The unconjugated oxosteroids were converted to their oximes, selectively isolated on a cation...
Observations on essential biochemical data profile in connection with restorative proctocolectomy in humans : vitamin B12 and fat absorption cited
(2001-10-18)
PATIENTS: The material includes 99 patients who consecutively received
handsawn pouch and ileoanal anastomosis, after mucosectomy. Sixty-five
patients were men and forty-four were women. The mean-age was 31.4 (range
17-59) ...