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The life and death of the notch intracellular domain
(2003-02-28)
The Notch signaling pathway is an evolutionarily conserved way of communicating between cells that contact each other. Notch is a single-transmembrane spanning receptor that interacts with single-transmembrane spanning ...
Sample preparation and mass spectrometry in proteome studies
(2004-05-07)
Proteome studies aim to link gene to function. Instead of screening for function in a specific protein as in classical protein chemistry, proteins are now screened against a specific phenotype, disease or metabolic state. ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution
(2004-05-14)
A striking characteristic of HIV is the enormous capacity of genetic
variation. Frequent mutations, deletions, insertions and recombination
events create a population of genetically related but non-identical
viruses ...
Linkage and association analysis in multiple sclerosis
(2001-09-03)
the possible genetic importance of the IFN-γ gene (IFNG) in MS, we performed a linkage and association study in 100 sib-pair families and 464 severity stratified patients and 266 controls. No linkage or association was found regardless of stratification for sex...
Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder : perspectives on origins of 'somatization'
(2004-04-21)
A range of somatic symptoms are more common in patients with major
depression than in the general population. Similar somatic symptoms and
depression have been described in mitochondrial disorders, in which
decreased ...
Maternity care in Zambia : with special reference to social support
(2004-01-07)
The Zambian woman starts childbearing early and gives birth to an average
of 5.9 children during her reproductive period. The already high levels
of maternal deaths are increasing in Zambia. Only 43 per cent of the
women ...
Sacroiliac pain-provocation testing in physiotherapy : time and force recording
(2004-08-27)
Introduction: Some of the tests used for examining pain arising from the
sacroiliac region are intended to provoke pain by using manually applied
forces. Previous reliability and validity studies of sacroiliac
pain-provocation ...
Autoimmune markers in autoimmune diabetes
(2003-12-19)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA class 11 haplotypes. HLA DR3-DQ2 and DR4-DQ8 ...
Studies on sterol 27-hydroxylase (CYP27A1)
(2004-01-30)
Human sterol 27-hydroxylase (CYP27A1) has been studied in the present thesis with focus on substrate specificity and possible role of the enzyme for prevention of accumulation of cholesterol and cholestanol in tissues. ...