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Rectal cancer : staging, radiotherapy and surgery
(2003-05-02)
radiotherapy with 5x5 Gy reduces local recurrence rates with more than 50% and may improve survival. This beneficial effect is seen both with conventional surgical techniques and TME based surgery. Preoperative radiotherapy may increase postoperative morbidity...
Socio-economic consequences of longstanding illness
(2002-08-09)
This thesis focuses an old research area of social medicine, the social and economic consequences of chronic illness and factors modifying this effect. Historically, illness was the main predictor of poverty. Since then, ...
Plasticity of the dopamine1 receptor and its signaling pathway
(2003-09-12)
Dopamine 1 receptor (D1R) belongs to the G protein coupled receptor superfamily with seven transmembrane domains. Previous studies from our laboratory showed that D1R availability in the plasma membrane of renal epithelial ...
Prognosis in acute myeloid leukemia and influence of monocytic markers : epidemiological, clinical and experimental studies
(2003-04-04)
mean annual incidence of 6.5 / 105 in adults. Under-notification, diversity and lack of specificity of codes, and selection of good prognosis patients were problems noted for the Cancer Registry.
Supplementation with cases from the Cause of Death...
Molecular mechanisms underlying the glucose-dependent transcription of the insulin and glucokinase genes in the pancreatic beta-cell
(2002-03-27)
Background: Insulin is of vital importance in the maintenance of the glucose homeostasis in mammals. This necessitates a tight regulation of both insulin release and biosynthesis. Although pancreatic beta-cells secrete ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Subcellular localization and signalling of Brutons tyrosine kinase (Btk)
(2002-11-28)
Brutons tyrosine kinase (Btk) is a non-receptor tyrosine kinase related
to the Src family of kinases. Mutations in various parts of the gene have
been shown to cause X-linked agammaglobulinemia (XLA), a primary
immunodeficiency ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Factors affecting attendance at population-based mammography screening
(2002-01-11)
. Non-attendance was more likely among women who smoked regularly, had not visited a doctor in 5 years, had never had cervical smear tests, had never used oral contraceptives or hormone replacement therapy, never drank alcohol, and who reported no breast...