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On laminins and laminin receptors and their roles in regeneration and myelination of the peripheral nerve
(2004-01-23)
for extracellular matrix molecules, like laminins.
Although many studies have shown laminin expression in the sciatic nerve, the developmental regulation and exact composition of the heterotrimers have not been revealed. Laminin alpha2, alpha4, beta1, beta2...
Comparison of stereotactic fine needle aspiration biopsy and core needle biopsy in breast lesions
(2004-04-16)
-FNAB and an average of three needle biopsies per lesion were taken. For S-CNB a needle with diameter 2.1 mm and 23 mm throw was used. Three needle biopsies per lesion were taken.
Paper I: Between May 1993 and June 1998 pre-operative S-FNAB and S-CNB were performed...
Quinine metabolism in man : emphasis on the 3-hydroxylation as a biomarker reaction for the activity of CYP3A4
(2002-04-05)
±8 %.
The role of CYP3A4 in the metabolism of quinine to 2'-quininone, (1OS)- and (1OR)-11-dihydroxydihydroquinine in vitro and the relative importance of these metabolites compared to 3-hydroxyquinine in the metabolism of quinine were studied in human liver...
Optimization of compliance in epidemiologic research and disease prevention : with special emphasis on PAP-smear screening
(2003-03-14)
The aim of this thesis was to investigate factors affecting attendance in screening for cervical cancer, and to evaluate various measures aimed at increasing compliance to self-administered postal questionnaires and screening ...
Distribution and pathophysiological role of amyloid precursor protein and presenilin 1 : characterization in rats and in vitro studies on the pathogenic arctic mutation
(2002-11-01)
's disease cases. In a few families the disease is caused by pathogenic mutations located on three different genes encoding presenilin (PS) 1, PS2 and APP.
PS is an important component of the complex executing gamma-secretase processing of APP. A detailed...
Interaction between researchers, firm managers and venture capitalists : the essence of biotechnology business
(2001-11-16)
The knowledge gained from the advances in biotechnology-related research
is the basis from which a number of opportunities are derived. The
potential of these opportunities have raised high expectations with
actors, ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
) on this process, a series of PGs were analyzed by semi quantitative reversed transcriptase polymerase chain reaction. The cells with epithelial phenotype showed increased expression of syndecan-2, syndecan-4 and hyaluronan synthase, and fibroblast-like cells...
Sacroiliac pain-provocation testing in physiotherapy : time and force recording
(2004-08-27)
Introduction: Some of the tests used for examining pain arising from the
sacroiliac region are intended to provoke pain by using manually applied
forces. Previous reliability and validity studies of sacroiliac
pain-provocation ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 and 20 months, and 36 age...