Search
Now showing items 1-10 of 72
Allergen-induced airway reactions in the pig in vivo : inflammatory mediators as targets for asthma therapy
(2002-03-01)
. Nonetheless, exogenous LTD4 induced bronchoconstriction and also bronchial vasoconstriction. MK-571 pre-treatment led to an elevated bronchial vascular conductance (BVC) upon allergen challenge compared to BVC in control pigs, seemingly due to blockade of a...
CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis
(2003-10-17)
Myasthenia gravis (MG) is a neuromuscular disease with muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR) on the skeletal muscle endplate. Cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) plays a...
Studies on proteins involved in the molecular regulation of insulin exocytosis
(2004-02-27)
-secreting beta-cells and the colocalization of Mint1 with Munc-18 suggest a functional role for Mint in the regulation of insulin secretion.
Exocytosis of insulin-containing secretory granules depends on phosphatidylinositol (PI) 4-kinase activity, since...
Ligand-receptor interactions and signaling cross-talk in the TGF-b superfamily
(2003-01-31)
The transforming growth factor-beta (TGF-beta) superfamily of secreted polypeptide growth factors forms part of an evolutionary conserved signaling pathway, present in diverse organisms from flies to humans, used in ...
Nestin regulation in the embryonic and adult CNS
(2001-11-09)
The developing mammalian central nervous system (CNS), i.e. the brain and spinal cord, is generated from neuroectodermal stem/progenitor cells lining the neural tube. The CNS stem/progenitor cells proliferate and migrate ...
Upholding older adults innate and inherent dignity within a caring context
(2002-10-10)
In the ethical ideals of autonomy and integrity reducing the level of abstraction is necessary in order to more easily be able to follow them in every day care practices. This is especially true concerning the effort of ...
Functional genomics at the interface of protein expression and biophysical analysis
(2004-02-18)
inhibitors of the enzyme.
Protein interactions of beta-catenin with Tcf4 were studied. This feature plays a central role in the wntsignaling pathway and has been proposed as a possible site of intervention for the development of anticancer drugs...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Bile in the oesophagus contributes to the development and complications of gastro-oesophageal reflux disease
(2002-05-10)
Objective: To clarify the relationship between duodenogastro- oesophageal reflux (DGOR) and gastro- oesophageal reflux disease (GORD) and its complications.
Methods: As persons who have had their gallbladders removed ...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. From HLA-DQ molecules, DQ8 (DQA1*0301- DQB1*0302) is the most prevalent IDDM haplotype in Caucasians, followed by DQ2 (DQA1*0201-DQB1*0501). Taken together, DQ8, DQ2 or both account...