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Studies on oxysterols : origins, properties and roles
(2003-09-05)
in the circulation was also investigated. 3betaHydroxy-5-cholestenoic acid and 3beta,7alpha-dihydroxy-5-cholestenoic acid were found to be formed from a lung specific sub-pool of cholesterol. 7alpha-Hydroxy-3-oxo-4- cholestenoic acid appears to be formed from...
Atherosclerosis of the ascending aorta as a risk factor for stroke after cardiac surgery : a study based on epiaortic ultrasound
(2004-04-23)
% of the ascending aorta diseased and those with more than 50% affected
were 95.3±0.9%, 91.8±2.1% and 65.0±14.6%, respectively (p<0.0001). The
distal-left side of the ascending aorta was associated with a 5-fold
increase in 5-year stroke rate.
Conclusions...
Comparison of stereotactic fine needle aspiration biopsy and core needle biopsy in breast lesions
(2004-04-16)
without any atypia. S-CNB diagnosed ILC in 20 (91 %) of the 22 patients, a mixture of ILC and invasive ductal cancer (IDC) in one lesion and ductal cancer in situ (DCIS) in the final lesion. In conclusion S-CNB was superior to S-FNAB in lesions where post...
Modulation of bile acid and cholesterol metabolism in health and disease
(2004-05-07)
An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis ...
Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals
(2003-08-14)
The ubiquitin-proteasome system plays a fundamental role in virtually every cellular process. Degradation of endogenous proteins by this system is the major source for antigenic peptides that are presented to MHC class ...
Notch receptor processing and CNS disease
(2002-08-30)
We have studied the relationship of Notch receptor processing and two diseases of the central nervous system: Alzheimer's disease (AD) and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy ...
The study of the Escherichia coli BarA-UvrY two-component system and its ability to sense the environment
(2003-03-07)
A bacterium always has to be prepared for rapid changes in its environment, e.g. a varying supply of nutrients. The rapid adjustment to new conditions largely relies on two-component systems (TCSs), typically consisting ...
Back pain post partum : clinical and experimental studies
(2003-03-07)
Background: Half or more of pregnant women experience back pain at some time during pregnancy. Even though back pain exists post partum, it is not well documented and detailed studies concerning different back pain ...
Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases
(2003-05-15)
was in fact the murine homologue of the human RDH5, based on the amino acid similarity, substrate specificity and protein expression patterns. These enzymes are thought to have a role in chromophore generation in the visual cycle. Genetical evidence...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...