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Skin sensitivity testing : a biophysical approach
(2002-04-12)
into four groups on the basis of age and gender.
In paper III, nickel sulphate in distilled water at various concentrations (0.15%, 0.31%, 0.62%, 1.25% and 2.5%) and 2% SLS were used to induce contact dermatitis of allergic and irritative type by using...
Spinal cord injury : mechanical and molecular aspects
(2002-05-10)
Traumatic spinal cord injury leads to full or partial paralysis and loss
of sensation below the level of injury. The annual incidence of spinal
cord injury in the United States is 3-5 per 100,000 and in Sweden is
1.5-2 per 100,000. This translates...
Nucleoside analog phosphorylation and mitochondrial enzymes : studies on molecular targets of the anti-leukemic compound 9-beta-D-arabinofuranosylguanine
(2004-03-26)
Nucleoside analogs are commonly used in treatment of cancer and viral infections. A way to improve the therapies would be to minimize the acquirement of resistance and side effects such as delayed cytotoxicity. Nucleoside ...
Regulation of protein degradation by virus derived repeated amino acid sequences
(2002-05-14)
downstream of ubiquitination and upstream of the interaction of ubiquitinated proteins with the proteasome. We also used p53 to generate a set of chimeras with different length and site of insertion of the GAr to monitore Mdm2- and E6-induced degradation. p53...
Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations
(2002-04-22)
different frequency of 1.4±0.1 mHz and 3.6±0.2 mHz respectively.
Alpha-haemolysin, a toxin secreted from Escherichia coli, induced calcium oscillations that were dependent on L-type voltage-gated calcium channels and release of calcium from InsP3 receptor...
Challenges and opportunities for tuberculosis prevention and care in an HIV epidemic area, Chiang Rai, Thailand
(2003-01-20)
Objective: To describe the impact of HIV/AIDS on the perceptions, attitudes and behaviors of various groups of people that may effect TB transmission, prevention and care.
Methods: The study was conducted in Chiang ...
On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids
(2003-12-19)
The origin of 4beta-hydroxycholesterol, a major oxysterol in human circulation, has previously been unknown. In this thesis, the formation and elimination of this compound are investigated by various techniques. The ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and theur relation to the inflammatory process in vivo
(2001-12-28)
spontaneous, as well as eotaxin-induced capacity to
transmigrate in vitro. This increased capacity is further enhanced within
2 hours after an allergen challenge in vivo without accompanying signs of
eosinophil activation in terms of increased PBE counts...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
induction therapy, in combination with ribavirin during treatment of naive patients, also resulted in a small but significantly more pronounced HCV RNA decline compared to standard dosing, in genotype non-1 infected patients but only day 2 and 7 during...