Search
Now showing items 1-10 of 93
Genetic regulation of autoimmune neuroinflammation
(2003-11-28)
on disease susceptibility. The aim of this thesis work has thus been to identify non-MHC loci/genes regulating MOG-EAE. Firstly, linkage analysis has performed in a (LEW.1AV1 x PVG.1AV1) F2 intercross, where the LEW background is susceptible and PVG...
Endogenous antioxidants in human skeletal muscle and adaption in energy metabolism : with reference to exercise-training, exercise-related factors and nutrition
(2003-03-14)
The antioxidant homeostasis is determined by a wide array of interacting cellular antioxidants, as well as being influenced by the homeostasis in energy metabolism. Changes in antioxidant homeostasis, as a consequences of ...
Studies on immunological mechanisms of induced arthritis in the rat
(2002-11-22)
Experimental arthritis induced with adjuvants shares many features with
the human autoimmune disorder rheumatoid arthritis (RA). The use of
arthritis models is therefore a relevant approach in the search for
pathogenic ...
Genetic studies of depressive symptoms
(2004-02-06)
biogenic amines like serotonin. The two different forms of the enzyme, MAOA and MAOB are both encoded by genes on the X chromosome. A linkage disequilibrium (LD) map was created by use of nine SNPs to determine the LD structure of the MAO locus. The locus...
Immunological studies in the brain and signaling pathways in experimental African trypanosomiasis
(2001-11-23)
to evaluate (X- and beta-chemokine induction in the brains of Sprague-Dawley rats infected with T. b. brucei and to identify the cellular sources of these chemokines. High production of MIP-2, RANTES and MIP-1alpha and to a lower extent, MCP-1 was found...
Genetic studies of atopic dermatitis
(2001-11-22)
in combination with elevated allergen-specific serum IgE levels (sp-1gE+). 3. Atopic dermatitis with a more severe phenotype (extreme AD) 4. The severity score of atopic dermatitis.
For the phenotype sp-IgE+ suggestive linkage (p<7x10-4) was found...
The effect of sex hormones on hemostasis and cardiovascular riskfactors in postmenopausal women
(2004-10-29)
The influence of cardiac riskfactors and sex hormones on hemostasis were
studied in healthy women (n=260) in Study I. Body mass Index (BMI),
dyslipidemia, surgical menopause, smoking and years since menopause were
associated ...
CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis
(2003-10-17)
Myasthenia gravis (MG) is a neuromuscular disease with muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR) on the skeletal muscle endplate. Cytotoxic-T-lymphocyte-associated ...
HMBG1 as a proinflammatory mediator in arthritis
(2003-05-02)
Proinflammatory cytokines are central in the pathogenesis of chronic arthritis and a new generation of therapeutics blocking TNF or IL-1 has improved outcome for many patients with inflammatory joint diseases. This thesis ...
Regulation of TNF-alpha : implications for health and disease
(2003-05-23)
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease.
When healthy 50-year-old men ...