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Uveal melanoma : cytogenetics, molecular biology and tumor immunology
(2002-09-13)
Uveal melanoma is the most common primary intraocular malignancy. The
metastatic spread is hematogenous and exclusively to the liver. Although
eye-sparing treatments are used more frequently the tumor-related
mortality ...
Radiological imaging of pulmonary emphysema : preoperative evaluation of candidates for lung volume reduction surgery
(2002-05-07)
Lung volume reduction surgery (LVRS) for pulmonary emphysema, first described by Brantigan in 1957, was re-introduced by Cooper et al in 1995. From a surgical point of view, information on the extent and distribution of ...
Population-based studies of body mass index, overweight and systolic blood pressure among Swedish young men
(2002-08-30)
among male international adoptees; and, 3) test the fetal origins hypothesis by analyzing relationships between aspects of fetal growth and overweight, and also between fetal growth and systolic blood pressure among singletons and twins in young...
Dopamine D2 receptor G protein coupling and it's regulation
(2004-01-08)
Dopamine (DA) receptors belong to the superfamily of G protein coupled
receptors. The D2 DA receptor is negatively coupled with adenylate
cyclase via pertussis toxin sensitive (Gi/o) G proteins. In the brain the
D2 DA ...
Genetics and inflammation in nerve injury-induced neurodegeneration
(2003-11-06)
plasticity in the adult animal.
Secondly, genetic influences on experimentally induced neurodegeneration and CNS inflammation were examined. Using different rat strains (i.e., DA(RT1av1), PVG.1AV1, LEW.1AV1, LEW1.N, BN(RT1n), and E3(RT1u)) significant...
The role of periodontitis in cardiovascular disease
(2004-01-30)
Periodontitis and cardiovascular disease (CVD) are both common diseases affecting a large part of the society. Both diseases are considered to have a chronic inflammatory origin. During the last decades research has focused ...
DNA-dependent protein kinase in normal and malignant cells : with special reference to anti-tumour agent sensitivity
(2003-01-03)
The DNA-dependent protein kinase (DNA-PK) is a DNA double strand break (DSB) repair enzyme, essential for the cellular response to DNA damaging agents. DNA-PK is also of importance for lymphoid development, since it includes ...
Aspects of N-glycosylation in human IgE
(2002-02-08)
, we found no major influence on structures in the C-epsilon-3- and C-epsilon-4-domains with monoclonal antibodies.
To further elucidate the structural implications of carbohydrates in IgE, it was necessary to establish a modelsystem. Production of a...
Studies of polyglutamine repeats and their biology in relation to disease
(2001-08-23)
, transcription factors and
polyglutamine containing proteins, including the normal forms of ataxin7
and ataxin-3 were recruited into the inclusions. Our results illustrate
for the first time the presence of activated caspase-3 in inclusions in a
human...
Stroke severity and outcome : in search of predictors using a population-based strategy
(2002-11-01)
bias on the frequency of different
stroke characteristics; 3) to establish the incidence of neglect and
anosognosia and their impact on disability; 4) to show the impact of
pre-stroke risk factors on stroke severity and case fatality; and 5) to
show...