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Organohalogen contaminants in humans with emphasis on polybrominated diphenyl ethers
(2002-02-08)
-10% in liver and 0.03-0.4% in adipose tissue, while the levels of OH-PCBs in breast milk were inconsiderable. Matrix specific differences were observed in OHPCB congener distribution. 2,2',3,4',5,5',6-heptachloro-4-biphenylol (4-OH-CB187) and 2...
Undergoing stem-cell transplantation : patients perceptions of symptoms, functional status and health-related quality of life
(2002-05-24)
of discharge from the ward (T6) and 7-15 weeks after the SCT (T7). A majority of the patients (92%) reported one or more ongoing symptoms already on admission (TO) and at this time-point the symptom manifestation was related to the malignancy the patient...
Tobacco smoking, vascular reaction and neutrophil activity in periodontal health and disease
(2003-01-03)
Tobacco smoking has considerable negative effects on periodontal health. The mechanisms behind these effects may be related to the inflammatory response.
In this thesis, the main aim was to study the influence of ...
Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation
(2003-01-24)
In allergic or asthmatic airways disease, upper and lower airways show a uniform eosinophilic inflammation of the mucosa, and bronchial hyperreactivity is a common finding. To study the co- variation of mucosal reactivity ...
Use of primary human hepatocytes for the elucidation of bile acid synthesis
(2003-01-03)
In the present investigation we cultured primary human hepatocytes on matrigel under serum-free conditions and studied bile acid formation. The following observations were made:
· The major steroid products excreted ...
Skin sensitivity testing : a biophysical approach
(2002-04-12)
The skin is regarded as the largest organ of the body, although it is only a few millimetres thick; it is also the interface between the environment and the body's vital structures.
Its large surface area is constantly ...
Biophysical aspects of contact dermatitis and its prevention
(2004-03-05)
The skin, one of the largest organs of the body, is composed of three layers: the epidermis, dermis and subcutis. The outer most part of the epidermis i.e., the stratum corneum - serves as a protective barrier between the ...
Cytomegalovirus after allogeneic haematopoietic stem cell transplantation : complications in the era of CMV-specific antiviral treatment
(2003-12-26)
-disease before day 100 after SCT has
decreased to 4-6%. The cost is an over-treatment with antiviral compounds
and the development of new types of problems. These studies were
undertaken to describe how the modern treatment modalities have changed
the pattern...
Molecular mechanisms involved in the growth of human uterine leiomyomas
(2002-11-14)
Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which ...
Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators
(2001-10-26)
Nuclear receptors (NRs) are ligand-dependent transcription factors. The DNA-bound receptors either positively or negatively regulate transcription of target genes. The receptors regulate transcription through interaction ...