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Cytoskeletal mechanisms in synaptic vesicle recycling
(2003-01-03)
This thesis explores cytoskeletal mechanisms involved in the recycling of synaptic vesicles. As an initial step it characterizes synapses formed by giant reticulospinal axons in lamprey and defines their use as a model ...
Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures
(2004-03-26)
, was followed in HSMC cultures as they differentiate from single
cell myoblasts to mutlicellular myotubes. Insulin signaling to
phosphatidyl inositol (PI) 3-kinase, extracellular regulated kinase (ERK)
1/2 mitogen activated protein kinase (MAPK) and protein...
Physical activity and fitness among adolescents in Sweden with a 20-year trend perspective
(2003-10-03)
was completed by 93% (n=542) of the invited adolescents and body dimension measurments and physical capacity tests was performed by 78% (n= 460) of the invited adolescents in 1995. In 1974, 395 adolescents was invited and all participated.
One third...
Genetic studies of depressive symptoms
(2004-02-06)
This thesis is focused on depressive symptoms particularly in late fife. Depressive symptoms are associated with serious negative outcomes a greater level of disability and with excess morbidity and mortality. This thesis ...
Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules
(2003-03-10)
of 1 pg/µL. Information about steroid structure was obtained from collision-induced dissociation (CID) spectra of 1 ng of steroid sulphate, while characterisation of the sulphate ester group required only 3 pg of material. Unconjugated oxosteroids were...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Subcellular localization and signalling of Brutons tyrosine kinase (Btk)
(2002-11-28)
found that Tec family
kinases bind to caveolin-1, a major structural component of caveolae
(rafts or microdomains) located in the plasma membrane. Finally, we
demonstrate that Cbl acts as an E3-ubiquitin ligase for Btk and that
ubiquitinated Btk...
Sacroiliac pain-provocation testing in physiotherapy : time and force recording
(2004-08-27)
Introduction: Some of the tests used for examining pain arising from the
sacroiliac region are intended to provoke pain by using manually applied
forces. Previous reliability and validity studies of sacroiliac
pain-provocation ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
A concept for treatment of sports related knee injuries
(2004-04-02)
The aim of the present thesis was, to evaluate local anaesthesia as ananaesthetic technique when performing knee arthroscopies, from a clinicaland economical point of view, and to describe the total costs for surgeryof ...