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Human cytomegalovirus immune evasion strategies
(2002-03-15)
Human cytomegalovirus (HCMV) is a member of the herpes virus family. HCMV is a ubiquitous pathogen, causing severe morbidity and mortality in immunocompromised patients, and is a major factor in congenital birth defects. ...
Blood saving in orthopaedic surgery
(2002-05-10)
509 (316) m] compared to 775 (316) m] in tile supine group (p<0.001).Total blood loss was also lower 1273 (458) ml in the lateral group vs. 1472 (407) mI in the Supine (p<0.05). Reduced hydrostatic blood pressure in the wound and hence reduced bleeding...
Determinants of ligand-induced nuclear receptor activation
(2004-05-13)
PXR was studied. We identified a critical amino acid residue, Gln285/Ile282, involved in the species specific activation observed for PXRs. Further, we suggest amino acid residue His407/Glu4O4 as important for the transcriptional activity of human...
Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients
(2002-05-24)
studied in patients with acid related diseases after repeated doses.
One hundred and fifty-two healthy Korean volunteers were phenotyped with debrisoquine and the metabolic ratio (MR) varied between 0.09 and 6.3, and all were thus extensive metabolizers...
Brain maturation, cognitive tasks, and quantitative electroencephalography : a study in children with attention deficit hyperactive disorder
(2002-11-22)
during concentration was studied comparing 36 children with ADHD (31 boys, 5 girls; mean age 10.5 y) and 63 controls (46 boys, 17 girls; mean age 10.0 y). QEEG techniques were used when the children performed the Vigilance Task of GDS. Compared...
The role of estrogen in growth plate chondrogenesis
(2002-11-29)
Overall body proportion is determined by the size of the skeleton, which in turn is determined by the rate and duration of longitudinal bone growth. Longitudinal bone growth occurs at the growth plate and is regulated by ...
SNP based strategies to study candidate genes for Alzheimer’s disease
(2002-11-08)
Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is a genetically heterogeneous disease characterized by progressive cognitive decline and memory impairment. The rare familial form of AD is ...
Angiogenesis in obesity and cancer
(2003-05-07)
Angiogenesis is the process of blood vessel growth from pre-existing vasculatures. In the adult, it is involved in certain physiological processes, such as in organ and tissue regeneration, wound healing, and in female ...
Targets for immune mediated killing of tumor cells and T cell functions in B-CLL
(2003-08-22)
There is a great need for developing and improving treatment alternatives in B-cell chronic lymphocytic leukemia (B-CLL). New therapeutical approaches based on the manipulation of the immune system enable establishment of ...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...