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Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system
(2002-05-17)
Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). ...
Cutaneous malignant melanoma aspects of prognostic factors and time : trends in a Swedish population
(2002-11-01)
One of the aims of this thesis was to assess the possible impact of primary and secondary preventive activities in the population of Stockholm-Gotland with the objective to reduce the incidence and mortality from cutaneous ...
Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids
(2002-05-03)
to contribute to hyperalgesia and allodynia. The cholecystokinin (CCK) gene- expression and CCK2-receptor gene-expression in dorsal root ganglion (DRG) cells is upregulated after sciatic nerve transection (axotomy). Since CCK acts as an anti-opioid peptide...
Platelet serotonin function and personality traits in affective disorder
(2002-03-29)
. function we investigated serotonin uptake kinetics, the serotonin transporter density and 5-HT2A receptor density. Using the Temperament and Character Inventory (TCI) and Karolinska Scales of Personality (KSP) we studied the personality traits in untreated...
Population-based studies of body mass index, overweight and systolic blood pressure among Swedish young men
(2002-08-30)
and overweight and systolic blood pressure in young adulthood on the other. Specific aims were to: 1) study time trends and socio-economic differences in body mass index and overweight among young men over the last decades; 2) study the occurrence of overweight...
Velocity controlled dynamometry and gait analysis : development of methods and applications
(2001-11-20)
The isokinetic systems developed in the present study can measure torque
in maximal voluntary and passive movements. The torque recordings may be
combined with surface EMG recordings from pairs of antagonistic muscles
involved ...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. Aa is produced...
Severe hypoxemia during apnea in humans : influence of cardiovascular responses
(2002-09-13)
When a diving human holds his or her breath, the heart beat slows and the blood vessels constrict in large portions of the body. In diving mammals such as seals, similar responses effectively conserve oxygen for the brain, ...
HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden
(2001-08-08)
Infection with human papillomaviruses (HPV) types 16 and 18 is the major
cause of cervical neoplasia. Although a high proportion of cervical
cancers (CXCA) harbor HPV genomes, only a small number of women infected
with ...