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Immunopathogenic mechanisms in inflammatory myopathies
(2002-11-14)
cells and muscle fibers, implicating a role for these cells in the immunopathogenesis of myositis. Endothelial cells of capillaries expressed the cytokine interleukin (IL)-1 alpha and were in many cases morphologically changed, resembling endothelial...
Significance of polymorphisms in human xenobiotic metabolising enzymes
(2002-12-20)
response to PAH exposures. Different allelic variants (genetic polymorphisms) have been described for several xenobiotic metabolising enzymes including cytochrome P4501AI (CYP1A1), glutathione transferase M1, P1 and T1 (GSTM1/P1/T1), microsomal epoxide...
From data to decision : a case study of controversies in cancer risk assessment
(2002-11-01)
the chlorinated solvent trichloroethylene (CAS no. 79-01-6). The purpose of the present study is to discuss (1) why risk assessors come to different conclusions, (2) how scientific data are used in risk assessment, and (3) how scientific uncertainty is handled...
Genetic and experimental studies of seasonal affective disorder and related phenotypes
(2003-03-14)
Seasonal affective disorder (SAD) is a subtype of recurrent depressive or bipolar disorder, in which episodes reoccur and remit during a particular season each year. A genetic component in vulnerability to winter SAD has ...
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(2004-04-02)
RNA expression and amplification of the multidrug resistance gene (MDR-1). The MDR-1 gene amplification correlated also to the expression levels of the P-glycoprotein. In the doxorubicin resistant U-1285dox900 cells, the resistance correlated with the MRP1 gene...
Body function and activity after acute stroke : physiotherapy perspectives
(2004-04-02)
length of stay (LOS), so as to facilitate planning of the
subsequent level of care. Study population 1.
II. We assessed 115 patients 65 years and older 10 days after stroke and
at discharge to investigate the relationship between clinically assessed...
Home care of persons with long-term mental illness : nurses and mental health care workers' experiences of how changes in the organisation of psychiatric services have changed their work
(2003-08-29)
as a conflict concerning intrusion into patient s privacy. Four main themes were identified; 1/ Intruding in the home of the patient; 2/ Experiencing fluctuating boundaries; 3/ Respecting or transgressing the right to privacy; and 4/ Situating mutual...
Studies in sporadic inclusion body myositis
(2003-05-15)
Aims: The general aims of the present study were to increase the understanding of the disease process in s-lBM by analysing the cytoskeletal structure in muscle fibres and their regeneration potential; and also to evaluate ...
Ischemic brain damage following transient and moderate compression of sensorimotor cortex in Sprague-Dawley and diabetic Goto-Kakizaki rats
(2004-03-05)
Several animal models have been developed to facilitate the investigation of biochemical, physiological, and neurological events after cerebral ischemia. In this study we present a new animal model which reliably describes ...
Modelling biomolecular interactions
(2003-05-16)
Computational approaches for understanding and aiding in molecular biology has increased in significance over the last decades, where a wealth of biochemical experiments have provided a solid ground for developing computer ...