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Pathogenetic studies of adjuvant-induced arthritis
(2002-11-15)
of injection.
In squalene-induced arthritis the non-major histocompatibility complex (non-MHC) genetic contributions are mainly derived from two regions, the Oia2 quantitative trait locus (QTL) on rat chromosome 4 and the Oia3 QTL on rat chromosome 10...
Specificity of neurotrophins in the nervous system : a genetic approach to determine receptor engagement by neurotrophins
(2004-01-02)
for the neurotrophins to display compensatory effects. Further comparison of the loss of neuronal numbers between neurotrophin and Trk receptor knock-outs have suggested a role for NT3 signalling through its non-preferred receptors, TrkA and TrkB.
In this thesis...
STAT5 expression and regulation in mammary epithelial cells
(2004-01-09)
of differentiation. Our data suggest that EGF repression of STAT5 expression through the ras/raf/MEK/MAPK and PI-3 kinase pathway is responsible for the lower expression during proliferation.
The 5' flanking region of the mouse STAT5A gene was isolated and four...
Neuromechanical control of the spine
(2003-05-23)
Control of the spine is complex. The spine is inherently unstable and dependent on the contribution of muscles. Yet there is considerable redundancy in the motor system with many muscles that act on the trunk.
This ...
Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers
(2002-08-16)
by complement, activated by naturally occuring antibodies in man binding the Galalpha1,3Gal (cc-Gal) carbohydrate epitope on pig tissues. Although cellular xenografts are not lost in a HAR, antibodies have been shown to decrease graft survival in pig to mouse...
Individual health, neighborhood characteristics, and allocation of primary health care resources
(2003-08-08)
, at the second level. In study 3 6,861 individuals from SALLS, interviewed in 1990/91 were followed until December 31, 2000, for CHD incidence events. Individual characteristics were age, sex, education, housing tenure, smoking habits, and a social participation...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants
(2003-11-24)
-I transcription factor, and two sites in the promoter were found to bind Sp1 and Sp3. Mutants with only three altered key nucleotides prevented binding of Sp1/Sp3 and resulted in a marked decrease of transcriptional activity. The promoter displayed typical...
Health care financing in China : equity in transition
(2002-08-12)
The aim of the thesis is 1) to assess equity in the provision, financing and utilization of health services in the study counties, after the launching of the Chinese health reform, in relation to income and health status, ...
Immunomodulation and immunopathogenesis in autoimmune disease with emphasis on autoimmune neuritis and arthritis
(2003-02-26)
Experimental autoimmune neuritis (EAN) and arthritis are CD4+ T cell mediated autoimmune animal models for the study of immunomodulation and immunopathogenesis of human Guillain-Barré syndrome (GBS) and rheumatoid arthritis ...