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Dendritic cell and IgA responses in SIV and HIV-1 pathogenesis
(2004-04-28)
Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV-1) can infect different subsets of dendritic cells (DC). Such cells may therefore not only be involved in the generation of recruitment of ...
Role of mast cell-derived mediators for leukocyte / endothelium-interactions and microvascular mechanisms in inflammation and in anaphylaxis
(2003-02-13)
The overall objective of this thesis was to study the roles of mast cell-derived mediators for leukocyte/endothelium interactions and microvascular mechanisms in inflammation and in anaphylaxis, using mast cell-deficient ...
Smith-Lemli-Opitz syndrome : a disorder of cholesterol synthesis : diagnosis, treatment and pathogenetic aspects
(2002-09-06)
precursor 7-dehydrocholesterol was consistent with deficient activity of the enzyme in the last step of the synthesis, 7-dehydrocholesterol-7-reductase.
The discovery raised hopes of developing diagnostic methods, finding strategies for treatment...
Low density lipoprotein (LDL) heterogeneity : implications for cardiovascular disease and genetic influence
(2003-03-21)
The low density lipoprotein (LDL) particle population is heterogeneous with regard to several structural and functional properties that may influence its atherogenic potential. A preponderance of small, dense LDL is ...
Pulmonary tuberculosis and HIV interaction in a setting with a high prevalence of HIV : clinical, diagnostic and epidemiological aspects
(2002-05-17)
The overall aim of this study was to elucidate the influence of HIV infection on the occurrence, clinical presentation, diagnostic yield and transmission of M tuberculosis among consecutive out-patients with symptoms ...
Structure-function studies of GDNF and other members of the TGF-beta superfamily
(2002-10-22)
The glial cell line-derived neurotrophic factor (GDNF) family is a
distant subclass of the TGF-beta superfamily. The GDNF family of ligands,
consisting of GDNF, neurturin (NTN), artemin (ART) and persephin (PSP),
are potent ...
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(2004-04-02)
Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of ...
Expression of stimulatory and inhibitory molecules in interactions between natural killer cells neurons
(2003-05-02)
Natural killer (NK) cells are important effector cells of the innate and the early induced immune defense. In the nervous system they appear early during inflammation and have been ascribed a role in clearance of certain ...
Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis
(2003-11-13)
How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which ...
Young men's sexuality and sexually transmitted infections in Zambia
(2002-10-04)
, 26% had suffered from an STI and many of them had gone to the private clinics for treatment. Majority (91%) of the men in Chiawa, compared with less than half in Misisi (4 1 %) said they considered themselves to be at risk of contracting HIV infection...