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CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis
(2003-10-17)
polymorphisms (SNPs) contribute most significantly to the variation in a population.
To determine an association between the genetic polymorphisms of the Ctla-4 and MG, the A/G SNP in CDS 1 at position +49 (A/G+49) and a C/T SNP in promoter at position 318 (C...
Post-traumatic stress disorder and life events among recently resettled refuges
(2002-09-27)
Background: In refugee health, one topic is how important posttraumatic stress disorder (PTSD) is from a public health point of view. The present study was initiated in order to study the prevalence of PTSD through structured ...
Neurotoxicity of methylmercury : analysis of molecular mechanisms and behavioral alterations
(2002-04-05)
MethyImercury (MeHg) is a global pollutant that is toxic for the nervous system, especially during development. Contaminated fish is the main route of human exposure. Recent studies have indicated that neurological alterations ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
-99 according to an extensive investigational protocol. A presumptive explanation of the stillbirth was established in 91% of the cases. The most common factors associated with intrauterine fetal death could be identified as infections (24%), placental...
Elucidation of pro-apoptotic signaling induced by cisplatin
(2003-02-07)
A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. ...
HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden
(2001-08-08)
Infection with human papillomaviruses (HPV) types 16 and 18 is the major
cause of cervical neoplasia. Although a high proportion of cervical
cancers (CXCA) harbor HPV genomes, only a small number of women infected
with ...
Allergic inflammation in children with pet allergy and asthma : mechanisms, markers and clinical consequences
(2002-05-10)
Immunological background: Allergic inflammation is a multiple-step process with many actors, where eosinophils and the release of their granula proteins play an important role. The recruitment of eosinophils is a crucial ...