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Toxin production in clostridium difficile
(2004-05-20)
Clostridium difficile is a is a Gram potential human pathogen. It causing symptoms ranging from mild C. difficile associated diarrhea (CDAD) to severe inflammation of the colon including pseudomembranous colitis and fulminant colitis. Over 300 000...
Mechanisms of activation of the hypoxia-inducible transcription factor 1a
(2002-04-05)
the involvement of HIF-1 alpha with transcriptional cofactors in regulating gene expression. We have shown that HIF-1 alpha conditionally interacts via two distinct transactivation domains with the coactivators CBP1/p300, SRC-1 or TIF2 in addition to the nuclear...
Human papillomavirus in tonsillar cancer
(2002-11-01)
. Importantly, the oncogenes of HPV-16, namely E6 and E7, are generally expressed in tonsillar cancer. It has been suggested that HPV positive and negative tonsillar cancer differ with respect to histopathology, oncogene profile as well as patient group features...
Factors of importance for radiosensitivity of tonsillar carcinoma
(2002-05-24)
Radiotherapy (RT) alone or in combination with surgery is the only curative treatment of tonsillar carcinoma (TC). As distant metastases are rare the loco-regional control is the most important factor determining survival. ...
Molecular studies of Wig-1, a p53-induced zinc finger protein
(2003-11-14)
nuclear proteins are regulated by acetylation. Here, we have studied whether Wig-1 is also posttranslationally modified by acetylation. We found that Wig-1 interacts with p300 and that it is a substrate for p300/CBP-mediated acetylation. Moreover, we found...
The normal and ACL deficient knee : an in vivo three dimensional kinematic and electromyographic analysis
(2002-12-27)
translations to within normal. For the MRI study, movement of the contact points between the medial and lateral condyles was posterior 12.5 mm vs. 13.8 mm, laterally 0.6 mm vs. 1.4 nun and inferiorly 6.2 mm vs. 9.7 mm when flexing to 30'. From 300 to 600...
The use of mass spectrometry and DNA technology in the investigation of hemoglobin disorders
(2003-03-07)
Hemoglobin (Hb) disorders, which severely affect nearly 300,000 newborns every year, have become a global problem. The disorders manifest a wide spectrum of clinical symptoms ranging from asymptomatic to lethal conditions. Inheritance or spontaneous...
Non-enveloped virus infection probed with host cellular molecules : a structural study
(2002-08-12)
group of small non-enveloped viruses belonging to a well- characterized virus family. The prototypic picornavirus consists of a singlestranded positive-sense RNA molecule that is encased by a protein capsid approximately 50Å thick and 300Å in diameter...
Toxicity of smokeless tobacco in human oral epithelium with emphasis on carcinogen metabolism and regulation of programmed cell death
(2002-10-10)
) transcripts were demonstrated including ]AL 1A2, 2C, 2D6, 2E1,
3A4/7 and 3A5. 'typical CYP substrates, including ethoxyresorutin,
methoxyresorufin and chlorzoxazone, were delectably oxidized in vitro and
metabolism of the tobacco-specific N-nitrosamine 4...
Sexual dysfunction and other distressful symptoms in cervical cancer survivors
(2002-02-15)
lubrication (relative risk [RR] 2.8 as compared to controls), reduced genital swelling at arousal (RR 1.5), reduced vaginal length (RR 6.1) and vaginal elasticity (RR 7.1), dyspareunia (RR 4.4), straining to void (RR 21.8), lymphoedema (RR 8.1) and distress...