Search
Now showing items 1-10 of 150
Hypoxia inducible factor 1alpha : molecular mechanisms of regulation
(2002-05-24)
Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of genes in response to low oxygen, or hypoxia. It is thus also a key factor in the regulation of angiogenesis in response to ...
Studies on oxysterols : origins, properties and roles
(2003-09-05)
Oxysterols are derivatives of cholesterol present at low concentrations in a variety of physiological compartments. The major oxysterols in human circulation are formed from pools of cholesterol that may be distinguished ...
Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers
(2002-08-16)
a much more efficient anti-pig antibody absorber than pig thyroglobulin and Galalpha1,3Gal disaccharides. CHO-K1, 293T, COS7m6, Sp2/0 and High-Five cells stably expressing PSGL-1/mIgG2b with and without the porcine alpha1,3 galactosyltransferase were...
Nephrin cellular trafficking and intracellular interactions
(2004-04-23)
of the project, we investigated the subcellular localization of 21 missense mutants identified in CNF patients using embryonic kidney cells (HEK293). Immunostaining and Immunoelectron microscopy of stable transfected cells expressing these nephrin mutants...
Extremly low frequency magnetic fields and breast cancer
(2003-05-07)
Extremely low frequency magnetic fields (ELF EMF) arise around all electrical leaders and equipment that is ran by electricity. In our modem society basically everyone is therefore to some extent exposed to magnetic fields. ...
Studies of polyglutamine repeats and their biology in relation to disease
(2001-08-23)
anticipation were analyzed by RED for the
presence of CAG repeat expansion. A 150-240nt CAG repeat was found to
cosegregate with the disease (p<0.000001, n=66). Shortly thereafter, the
SCA7 gene was cloned, which opened an avenue for pathophysiological
studies...
Molecular and diagnostic aspects of the protein p41 of HHV-6 and silencing of the CD46 receptor by RNA interference
(2003-05-23)
Multiple sclerosis (MS) is one of the most common diseases of the central nervous system (CNS), leading to sensory and motor disability in young adults. There is no efficient treatment of the disease. Its etiology is ...
Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes
(2003-10-24)
a P488T frameshift and a premature stop yielding a protein with a ten amino acid truncation and an altered sequence of the six most C-terminal amino acids. Heterologous expression of this variant allele, CYP3A4*20, in yeast and HEK 293 cells...
Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene
(2003-05-23)
, but not by TCDD, was revealed by mutation of Tyr 320 to Phe. Competition of AhR-bound [3 H]TCDD by PRQ was completely abolished in extracts form HEK293 cells expressing the mutant Gal4-Y32OF protein, while TCDD-binding was unaffected. These findings indicate...
Longitudinal studies of human papillomavirus infection : with special reference to screening for cervical cancer and treatment of CIN
(2003-10-03)
% of women with a persistent HPV infection, had an abnormal colposcopy. Histopathologically confirmed CIN grade 2 or 3 was found among 28/98 (29%) of women with HPV DNA persistence and among 2/93 controls.
Conclusions: Since HPV DNA is rapidly cleared...