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Regulation of mitochondrial transcription and mtDNA copy number in mammals
(2003-05-02)
for mitochondrial transcription. With the help of profile-based BLAST searches and Mtf1p peptide sequence, we were able to identify two novel mammalian mitochondrial transcription factors called TFB1M and TFB2M. Using pure recombinant mitochondrial RNA polymerase...
Molecular aspects of glutathione synthetase deficiency
(2004-02-27)
are rare, the most frequent disease is caused by mutations in the GS encoding gene (GSS) located on chromosome 20q11.2. Approximately 30 different mutations have been reported from a total of nearly 70 patients. Patients with GS deficiency present with a...
Skin cancer prevention : readiness to change sun-related behaviours
(2004-04-02)
The general aim of this thesis was to collect data relevant for skin
cancer prevention and to investigate the applicability of the
Transtheoretical Model for sun-related behaviour. Also, to assess the
readiness to change ...
Non-enveloped virus infection probed with host cellular molecules : a structural study
(2002-08-12)
the antigenic epitope of poliovirus. This may partially explain why poliovirus has only three serotypes while the rhinovirus major group has nearly 90 serotypes. A third prototypic picornavirus, echovirus 1, uses alpha2beta1 integrin as its cellular receptor...
Molecular basis for the anti-inflammatory properties of chlomethiazole
(2003-09-08)
the cytochrome P450 2E1 (CYP2E1), as well as inflammation associated with alcohol liver disease (ALD) by inhibiting cytokine expression. The aim of the present study was to characterise the molecular mechanisms of action of CMZ, as a basis to understand...
Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors
(2002-05-16)
Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells ...
Proteins influencing the integrity of meiotic chromosome dynamics
(2002-08-09)
that include the AE (formed by two meiosis-specific proteins, SCP2 and SCP3) and a second protein complex, composed of cohesins, which promotes sister chromatid pairing. Inactivation of SCP3 in male mice abolishes AE formation, resulting in chromosomal pairing...
Development of new approaches for tumor suppressor genes identification
(2002-12-26)
representation (NR). A pilot experiment using NR probes demonstrated the power of the method, and we successfully detected Chr 3 NotI clones deleted in ACC-LC5 and MCH939.2 cell lines. NotI arrays will speed up cancer research very significantly and can replace...
Short-chain dehydrogenases/reductases : structure, function and motifs of hydroxysteroid dehydrogenases
(2002-11-15)
of the apoform of 3 beta/17 beta-HSD have been determined at 1.2 A resolution. The structure, kinetic analysis of wild-type and mutants (Y148F and H182L) with residue exchanges in the binding loop, and docking experiments make it possible to explain the steroid...
Biomolecular characterization of mumps virus genotypes with varying neurovirulence
(2002-05-09)
to the C genotype and two were of the D genotype. Two variants were found within the C genotype, Cl virus strains causing meningitis and C2 virus strains associated with parotitis.
When virus strains belonging to the same genotype were compared intra...