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Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation
(2003-03-06)
Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression ...
Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence
(2003-08-08)
upregulation of FGF-2/FGFR1 signaling was established, whereas the gpl30 signaling components (CNTF, IL-6, LIF, CNTFRalpha, LIFR, IL-6R or gpl30) were maintained at young adult level in the aged spinal cord, indicating that FGF/FGFR1 signaling may be involved...
In vivo studies of cell cycle regulating proteins in rats during liver regeneration and during promotion of liver carcinogenesis
(2004-05-20)
There are more than one hundred different types of cancer in humans. However, the major platform for all types of cancer is automous and uncontrolled cell division and though most types of cancer are possible to treat and ...
Proinsulin C-peptide : membrane interactions and intracellular signaling
(2004-05-13)
renal tubular cells were studied using
the indicator fura-2/AM. The results showed that human Cpeptide and its
C-terminal pentapeptide, but not the des(27-3 1)C-peptide or scrambled
C-peptide, elicit a marked increase in [Ca 21 +] i . This effect...
Smith-Lemli-Opitz syndrome : a disorder of cholesterol synthesis : diagnosis, treatment and pathogenetic aspects
(2002-09-06)
In 1993 it was first suggested that the Smith-Lemli-Opitz syndrome (SLOS), described almost 30 years earlier as a malformation syndrome, is caused by defective synthesis of cholesterol. Hypocholesterolaemia and accumulation ...
Attention-deficit/hyperactivity disorder : alterations of motor behaviour and dopaminergic transmission
(2004-05-14)
Altered catecholaminergic neurotransmission in the brain has long been
thought to be of importance in the regulation of motor behavior and
cognitive performance in children who had symptoms of distractability,
impulsivity ...
Novel aspects of Na+,K+-ATPase
(2002-09-13)
Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and ...
Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects
(2002-09-11)
The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat ...
Molecular studies of Wig-1, a p53-induced zinc finger protein
(2003-11-14)
The fact that p53 is one of the most commonly mutated gene in human tumors indicates that it has a key role in tumor suppression. p53 accumulates after DNA-damage and other types of cellular stress, leading to the initiation ...
Depression and partner violence before and after childbirth
(2004-05-21)
This thesis comprises studies of prevalence and indicators of depressive mood during pregnancy, two months and one year post partum as well as on studies of prevalence, and indicators of being hit by the partner in the ...