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Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases
(2003-05-15)
Retinoids (vitamin A derivatives) are vital nutrients that regulate a variety of physiological processes, including embryonic development, postnatal growth, reproduction, cell differentiation as well as maintenance of the ...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
11beta-Hydroxysteroid dehydrogenase type 1 as a pharmacological target in metabolic disease
(2004-04-08)
The metabolic syndrome is a collection of associated disorders, affected by lifestyle, genetic predisposition and environment, and emerges as a consequence of the Western society lifestyle. It describes a variety of ...
Biocomputational studies on protein structures
(2002-08-16)
Biology in the post-genomic era produces large amount of data. This, in combination with the need for efficient algorithms to find genes in the genomic material, has brought a renaissance into the field of computational ...
Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules
(2003-03-10)
analytical methods, nano-ES mass spectrometry was applied to the characterisation of a lipophilic modulatory factor isolated from mouse brain. The factor, which activated the retinoid X receptor (RXR), was extracted from mouse brain incubates, purified...
Morbidity in Ménières disease : aspects on quality of life and triggering factors
(2002-11-22)
Menieres disease is an inner ear disorder of unclear origin, characterized by severe attacks of simultaneously appearing fluctuant hearing loss, vertigo, tinnitus and a feeling of aural fullness. The disease has a well-known ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Microfluidic analysis and parallel confocal detection of single molecules
(2003-09-12)
) was utilized to investigate hydrodynamic pressure driven flow in microchannels with a cross section of 50 x 50 µm2. The flow itself, was detected non-altered or noninvasively, since only tiny (a couple of nanometer in size) dye-molecules were entrained...