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On the pro-apoptotic mechanisms of the antitumor drugs doxorubicin and interferon-alpha
(2003-11-07)
, both with respect to DXR and IFN-alpha.
We demonstrated the requirement of Bak and Bax for the induction of apoptosis by DXR by using bax- as well as bak-deficient mouse embryo fibroblasts (MEFs). The BH3-only protein, Bik, which is induced...
Parasite signalling and host responses in experimental and human African trypanosomiasis
(2002-08-08)
, accompanied by high TLTF levels and low anti-TLTF antibodies at day 3 post-infection (p.i.); 21 days p.i low TLTF levels together with increased anti-TLTF antibodies was observed. In contrast, IFN- gamma/- mice exhibited very low parasitemia, low TLTF and anti...
Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation
(2003-01-24)
to the eosinophilic type of inflammation. Also in healthy volunteers exposed to swine dust by weighing pigs for 3 hours in a swine confinement building, a procedure known to induce an intense neutrophilic airway inflammation (organic dust toxic syndrome), both nasal...
Biophysical aspects of contact dermatitis and its prevention
(2004-03-05)
The skin, one of the largest organs of the body, is composed of three layers: the epidermis, dermis and subcutis. The outer most part of the epidermis i.e., the stratum corneum - serves as a protective barrier between the ...
Targets for immune mediated killing of tumor cells and T cell functions in B-CLL
(2003-08-22)
There is a great need for developing and improving treatment alternatives in B-cell chronic lymphocytic leukemia (B-CLL). New therapeutical approaches based on the manipulation of the immune system enable establishment of ...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Minimally invasive hernia surgery
(2003-04-25)
Minimally invasive laparoscopic and open tension-free techniques have been evolved during the 1990's. Different laparoscopic techniques have been used, where the totally extraperitoneal hernioplasty (TEP) is a technically ...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Linkage and association analysis in multiple sclerosis
(2001-09-03)
the possibility of locating susceptibility genes in 5p, 12q23 and 7ptr-15 (Paper I). The highest NPL score in Nordic affected sibpair families was found in 3p14-13. This region is not only formerly suggested by British and Canadian screens, but also contains...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...