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Bioinformatic methods in protein characterization
(2002-11-08)
Bioinformatics is an emerging interdisciplinary research field in which mathematics. computer science and biology meet. In this thesis. bioinformatic methods for analysis of functional and structural properties among ...
T cell production of cytokines, neurotrophins and MHC regulation in autoimmune neuroinflammation
(2002-05-24)
Multiple Sclerosis (MS) is a common disabling disease of the central
nervous system (CNS). A role for the major histocompatibility complex
(MHC) in disease susceptibility is established but not completely
understood. ...
Prognosis in acute myeloid leukemia and influence of monocytic markers : epidemiological, clinical and experimental studies
(2003-04-04)
. In the study of incidence and registration, also ALL and unspecified AL were included due to delimitation difficulties. Four registries were used for case finding and diagnoses were verified from medical records. 260 cases of acute leukemias were found giving a...
Studies on immunological mechanisms of induced arthritis in the rat
(2002-11-22)
erosions of bone and cartilage. The
influence of MHC as well as non-MHC genes has been demonstrated in both
these models.
In the first paper we evaluated the contribution of CD4+ and CD8+ T cells
respectively, to development of disease. This was performed...
The effect of sex hormones on hemostasis and cardiovascular riskfactors in postmenopausal women
(2004-10-29)
The influence of cardiac riskfactors and sex hormones on hemostasis were
studied in healthy women (n=260) in Study I. Body mass Index (BMI),
dyslipidemia, surgical menopause, smoking and years since menopause were
associated with an increase of 28...
Molecular genetic aspects of renal cell carcinoma development
(2003-04-25)
within the region between D14S617 and D14S260 was also associated with a significantly shorter survival (p=0.02). In conclusion, the high frequency of distal 14q LOH supports the relevance of this alteration for the development of RCC (paper V...
Genetic epidemiological approaches to the study of risk factors for cardiovascular diseases
(2003-05-07)
Cardiovascular disease (CVD) is one of the most common causes of death in most developed countries. Genetic and environmental factors influence CVD and its risk factors in a complex fashion. Parallel to this, new statistical ...
Germline CDKN2A/ARF alterations in human melanoma
(2002-03-01)
Approximately 10% of cases of human cutaneous malignant melanoma (CMM) have been estimated to occur in individuals with a familial predisposition, frequently in association with dysplastic nevus syndrome (DNS). The genetics ...
Vector development for suicide gene therapy
(2002-05-03)
-mediated integration in several cultured cell lines as well as
primary human donor T-lymphocytes (Paper IV).
We have prepared suicide gene therapy vectors containing HSV-tk and OuaR
selection marker fusion gene in extensively optimised retroviral backbone
SF91...
Severe hypoxemia during apnea in humans : influence of cardiovascular responses
(2002-09-13)
When a diving human holds his or her breath, the heart beat slows and the blood vessels constrict in large portions of the body. In diving mammals such as seals, similar responses effectively conserve oxygen for the brain, ...