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Genetic regulation of autoimmune neuroinflammation
(2003-11-28)
on disease susceptibility. The aim of this thesis work has thus been to identify non-MHC loci/genes regulating MOG-EAE. Firstly, linkage analysis has performed in a (LEW.1AV1 x PVG.1AV1) F2 intercross, where the LEW background is susceptible and PVG...
Regulation of TNF-alpha : implications for health and disease
(2003-05-23)
studies in human HepG2 cells. Allele frequency for the rare A- allele was 17% amongst 254 apparently healthy men of Swedish origin, aged 35-50 years. In 156 men, carriers of the rare allele had significantly lower TNF-alpha serum levels (p<0...
Estrogen receptor b in the urogenital tract of both male and female
(2002-05-24)
The central finding of this thesis is that estrogen receptors regulate androgen receptor expression: ERalpha unpregulates AR and ERbeta down-regulates AR. With this theme, we explored the physiological role of an ER-AR ...
Studies on head trauma complications with special reference to mild traumatic brain injury
(2004-03-05)
Traumatic brain injury (TBI) is a recognised public health problem.
Patients with mild traumatic brain injury (MTBI) represent the main part
of the total TBI population attending hospital. The aim of this thesis
was to ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...
Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases
(2003-05-15)
Retinoids (vitamin A derivatives) are vital nutrients that regulate a variety of physiological processes, including embryonic development, postnatal growth, reproduction, cell differentiation as well as maintenance of the ...
Tissue destruction in arthritis : experimental studies
(2003-11-14)
Destruction of joint cartilage and bone is one of the most serious consequences of chronic arthritis. Clinically, the standard assessment of joint destruction is performed by radiography. The sensitivity of radiographic ...
Morbidity in Ménières disease : aspects on quality of life and triggering factors
(2002-11-22)
Menieres disease is an inner ear disorder of unclear origin, characterized by severe attacks of simultaneously appearing fluctuant hearing loss, vertigo, tinnitus and a feeling of aural fullness. The disease has a well-known ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...