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Pain-related fear and movement : implications for physiotherapy and public health
(2003-01-17)
Long-term musculoskeletal pain is a large public health problem with serious consequences both for the individual and society. Fear-avoidance beliefs and catastrophizing are powerful cognitions in the process of developing ...
Skin sensitivity testing : a biophysical approach
(2002-04-12)
The skin is regarded as the largest organ of the body, although it is only a few millimetres thick; it is also the interface between the environment and the body's vital structures.
Its large surface area is constantly ...
Using SNPs to study complex genetic disease : a population and evolutionary genetics perspective
(2004-05-21)
Associating genes to complex genetic diseases has proven more difficult
than anticipated. Many genetic variants contribute small effects towards
an individual's disease predisposition in polygenic diseases, and ...
Experimental nerve injury : induced pain : mechanisms and modulation
(2004-03-26)
Chronic nerve injury-induced pain presents a therapeutic challenge since
such pain is often resistant to conventional analgesic drugs including
opioids. Better knowledge of the pathophysiological mechanisms underlying
nerve ...
Functional ability in non-ambulatory people with Duchenne muscular dystrophy or spinal muscular atrophy assessed with the EK scale
(2002-05-24)
with SMA. Among subjects with DMD, there was a significant change in the EK sum over five years (annual mean change 1.3 points, between 15-25 years of age) in contrast to subjects with SMA (0.2 points). In subjects with DMD or SMA treated with spinal...
Significance of polymorphisms in human xenobiotic metabolising enzymes
(2002-12-20)
Cigarette smoke is the primary cause of lung cancer but urban air pollution and certain occupational exposures have also been found to elevate the incidence of lung cancer. These exposures contain polycyclic aromatic ...
Combined radiology and cytology in the diagnosis of bone lesions : a study of 494 patients
(2002-11-22)
diagnosed 1993 through 1998 were collected from the original reports. The study included four overlapping series: 1) 52 consecutive high grade osteosarcomas, 2) 83 consecutive myelomas/lymphomas, 3) 29 unselected lesions analysed for sample...
Enhancing T cell mediated immunity in DNA vaccination
(2003-11-21)
For centuries infectious diseases have been one of the main causes of death in the world. With the invention of vaccine technology 200 years ago, we have been able to impede and even eradicate several dangerous pathogens. ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...