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Molecular dynamics studies of water and biomolecules
(2002-05-24)
This thesis concerns different areas of molecular dynamics (MD) simulations. In the first part of the thesis the ability of liquid water models to mimic the real bulk water properties and the accuracy of the methods to ...
Human gonadotrophins for ovarian stimulation in infertility treatment
(2001-11-16)
Infertility problems are present in 10 to 15 % of couples of fertile age. Ovulatory dysfunction, as a single cause, can be successfully treated and in-vitro fertilisation (IVF) can help a considerable number of couples, ...
Regulation of dioxin receptor function by the Hsp90 chaperone complex
(2002-03-22)
In mammals the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors includes the dioxin receptor which is a ligand-dependent transcription factor which mediates biological effects of environmental ...
Endothelin and nitric oxide in the fetoplacental circulation
(2004-05-21)
Background: Normal fetal growth and development depend on a satisfactory uteroplacental and fetoplacental blood flow. This will ensure an adequate gaseous exchange and nutritional supply to the fetus. The importance of ...
Sarcoidosis : inflammatory mechanisms and markers of activity
(2002-10-25)
Sarcoidosis is a disease characterized by an accumulation of CD4+ T-lymphocytes in affected organs. Previous findings of an association between the HLA-allele DR17 and an accumulation in bronchoalveolar lavage fluid (BALF) ...
Central-block techniques for reliet of labour pain
(2004-04-23)
the lowest effective dose. In a prospective doubleblind study 243 patients were randomised to sufentanil 0.5, 0.75 and 1 µg/mI respectively, in combination with bupivacaine. The analgesic effect was similar in the three groups. While no lowest possible dose...
Intravasal microdialysis as a novel technique to monitor metabolism in myocardial ischemia and critical illness
(2003-05-07)
Rapid detection of post-operative myocardial ischemia is of great value in the treatment of patients undergoing cardiac surgery. With the methods readily available in modem thoracic intensive care units post-operative ...
Interventions for improved prescribing and dispensing of medicines in Nepal, Thailand and Vietnam
(2003-11-17)
217 facilities. III: 60 randomly selected private pharmacies as measured by 5 simulated client visits (SCM) and a semi structured questionnaire per pharmacy. IV: Pre post questionnaires to 34 randomly selected matched pairs of pharmacies. V...
Approaches for the localization and identification of human cancer genes
(2002-09-18)
approach.
Using extensive genetic approaches, we characterized a novel translocation t(1;3)(q32;q13.3) associated with familial renal cell carcinoma. By FISH mapping, the breakpoints were refined to a 5 cM region in 3q13.3 and a 3.6 cM region in 1q32. We...
Maternal outcome of pregnancy in Mozambique with special reference to abortion-related morbidity and mortality
(2002-05-08)
In the capital city of one of the least developed countries, and using a hospital-based approach, the general aim was to characterise women who have undergone illegally and legally induced abortions, and to show the magnitude ...