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Functional studies on the nuclear receptor Nurr1
(2004-04-28)
contains receptors for known ligands and it contains a large number of socalled "orphan receptors", for which ligands do not exist or have not been identified. Nurr1 is an orphan receptor that is mainly expressed in the central nervous system where it plays...
Endocrine tumour development : with special focus on chromosome arms 1p and 11q
(2002-03-29)
The overall goal of this thesis has been to characterise the involvement of chromosome arms 1p and 11 q in the development of endocrine tumours.
The MEN1 gene was analysed as a candidate tumour suppressor gene by screening for mutations...
Social differences in injury risk in childhood and youth : exploring the roles of structural and triggering factors
(2003-03-21)
of the household and parental country of birth.
Peer victimisation increases the risk of unintentional injury for a short period after an episode has occurred (1-15 minutes), but not thereafter. The effect is higher for children who are seldom or never...
Extremly low frequency magnetic fields and breast cancer
(2003-05-07)
Extremely low frequency magnetic fields (ELF EMF) arise around all electrical leaders and equipment that is ran by electricity. In our modem society basically everyone is therefore to some extent exposed to magnetic fields. ...
Young men's sexuality and sexually transmitted infections in Zambia
(2002-10-04)
, 26% had suffered from an STI and many of them had gone to the private clinics for treatment. Majority (91%) of the men in Chiawa, compared with less than half in Misisi (4 1 %) said they considered themselves to be at risk of contracting HIV infection...
Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human
(2004-01-29)
underlying the variation in CPA
kinetics.
In the HL-60 cell line and its multi-drug resistant (MDR) phenotype
HL-60R that was exposed to CPA, no measurable CYPs were induced by CPA
exposure. this indicates that the CYP inducibility in cells is poor.
CYP1B1...
Impact of peritoneal solute transport rate on nutritional status and clinical outcome in peritoneal dialysis patients
(2003-04-16)
or unchanged PSTR. Patients with a decrease in RRF>1.9 ml/min during the 1st year on PD had more often high CRP, higher D/P Cr, and higher changes in D/P Cr compared to the patients with a decrease in RRR<1.9 ml/min. High CRP and low RRF were independent...
O6-methylguanine-DNA-methyltransferase and DNA mismatch repair in relation to drug resistance in malignant melanoma
(2004-03-26)
polymorphisms (SNPs) in melanoma patients belonging to families with a hereditary predisposition for melanoma and healthy individuals. In total 11 SNPs were detected, 5 in the 5'-noncoding region, I in exon 1, 2 in exon 3 and 3 in exon 5. Six of the alterations...
Dissection of immunity controlling spread and growth of Listeria monocytogenes in neuronal cells
(2003-11-07)
in such neuroinvasion; inducible nitric oxide synthase (iNOS) accounts partially for the protection. M< cells played the protective role in neuroinvasion by releasing IFN-γ but not through a perforin-dependent mechanism. By using mice lacking colony-stimulating factor 1...
Leukocyte-endothelial interactions in arteries in vivo : a new concept in the study of physiology and disease in large blood vessels
(2001-11-23)
and IL-1 beta OBS 1 P, as well as in unstimulated atherosclerotic mice, interactions are
abundant. Adhesive contacts between leukocytes and endothelium in
arteries are transient compared with venules in inflammation, a fact that
restricts the ability...