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Managers working conditions : stress and health
(2002-05-16)
(n=288, n=344, n=5.185) on the basis of which five cross sectional studies have been performed. They constitute this thesis. Three questionnaires were used and for a smaller group blood tests were analysed. Comparisons were made between male...
Regulation of cytokine receptors and activity markers in eosinophilic inflammatory processes
(2002-05-16)
and are removed. The cytokines IL-5, IL-3 and GM-CSF are of crucial importance for this course, and increased levels have been detected in serum and airways of asthmatic patients.
The main topic for this thesis was to investigate the role and regulation...
Studies on genetic hemochromatosis and the hepatotoxicity of iron
(2002-05-17)
The aim of this study was to investigate the mutations and clinical
expression of genetic hemochromatosis in patients and mechanisms involved
in the hepatotoxicity of iron in animal and cell- culture models.
In Swedish ...
Stiffness changes of the tympanic membrane in otitis media
(2002-05-03)
Acute purulent otitis media and otitis media with effusion, are common
diseases in childhood. Years later some of the children will get
"complications", such as retraction pockets and cholesteatoma, that often
need advanced ...
Ephrins off the beaten path
(2003-10-31)
and receptors is not limited to the developing nervous system but exhibits an astounding temporal and spatial diversity.
My initial work focused on a somewhat surprising phenotype in the ephrin-A5 null mutant. This mutant displays errors in the establishment...
Nuclear compartmentalization of viral and cellular proteins involved in gamma-herpes virus (EBV and HHV-8) mediated cellular transformation
(2003-11-07)
The aim of the work described in this thesis has been to characterize the nuclear compartmentalization of cellular and viral proteins involved in EBV or HHV-8 mediated cellular transformation. We have studied the EBV encoded EBNA-5 and its...
Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human
(2004-01-29)
showed
a dramatic regulatory effect on CYP2B1 mRNA.
We have evaluated the role of the polymorphic human CYP2B6 in CPA
bioactivation using sixty-seven human liver specimens that were genotyped
with respect to the CYP2B6*5 and CYP2B6*6 allelic variation...
Structure and biological properties of scavenger receptor MARCO
(2002-09-06)
for binding of unopsonized environmental particles such as
TiO2 and Fe203
To examine the regulatory mechanisms of MARCO, and its potential role in
disease, the structures of human and murine MARCO genes were determined.
Both genes have 17 exons, of which...
Monitoring pregnancy for improved perinatal outcome in Mozambique
(2002-11-27)
factors for preterm birth. Perinatal death occurred in 5.4% and 9.7% delivered SGA newborns. The obstetric cohort monitored provided valuable baseline data to be used as reference.
To create an alternative syphilis screening among pregnant women two...
Monitoring of antiepileptic drugs using microdialysis : methodological and clinical aspects
(2002-10-25)
In therapeutic monitoring of antiepileptic drugs (AEDs) the level of unbound drug at the sampling site should ideally equal the unbound concentration at receptor sites. Microdialysis enables direct sampling of the unbound ...