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Assignment and assessment of orthology and gene function
(2004-01-30)
Several genomes from different species have been sequenced over the last years, most notably the human genome. An important task of computational biology is to classify and functionally annotate the large amount of sequence ...
Glucocorticoids in the development and homeostasis of T lymphocytes
(2002-05-24)
Until recently the fact that glucocorticoids (GCs) play an essential physiological role in regulation of the immune system in health and disease was not fully appreciated. The main aims of this thesis were to investigate ...
Post-traumatic stress disorder and life events among recently resettled refuges
(2002-09-27)
Background: In refugee health, one topic is how important posttraumatic stress disorder (PTSD) is from a public health point of view. The present study was initiated in order to study the prevalence of PTSD through structured ...
Cognitive functioning in aging and dementia : the role of psychiatric and somatic factors
(2002-05-24)
This doctorial thesis concerns the role of psychiatric and somatic factors in aging and dementia. Five studies are included, all based on data from the Kungsholmen Project, a population-based longitudinal study of aging ...
Platelet serotonin function and personality traits in affective disorder
(2002-03-29)
Serotonin (5-HT, 5-hydroxytryptamine) is a neurotransmitter in the central nervous system which has been implicated m the aetiology and pathogenesis of affective disorders like depression and anxiety disorders. The ...
Uptake, disposition and acute effects of inhaled organic solvents : sex differences and influence of cytochrome P450 2E1 in human volunteers
(2003-10-17)
or toluene vapour at a dose equal to the Swedish occupational exposure limit, with and without intake of chlorzoxazone. The solvents were measured in inhaled air, exhaled air, capillary blood and urine. The levels of chlorzoxazone, its metabolite 6...
Approaches for the localization and identification of human cancer genes
(2002-09-18)
approach.
Using extensive genetic approaches, we characterized a novel translocation t(1;3)(q32;q13.3) associated with familial renal cell carcinoma. By FISH mapping, the breakpoints were refined to a 5 cM region in 3q13.3 and a 3.6 cM region in 1q32. We...
Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations
(2002-04-22)
different frequency of 1.4±0.1 mHz and 3.6±0.2 mHz respectively.
Alpha-haemolysin, a toxin secreted from Escherichia coli, induced calcium oscillations that were dependent on L-type voltage-gated calcium channels and release of calcium from InsP3 receptor...
Variable viral genes as genetic immunogens
(2003-01-17)
Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost-effective medical intervention against influenza is vaccination but this has to be repeated ...
Atopic dermatitis : clinical and epidemiological aspects in children up to four years
(2002-05-22)
Atopic dermatitis (AD) is a pruritic, chronically relapsing inflammatory skin disease; its aetiology is presumed to be multifactorial with interactions between genetic and environmental factors. In recent decades the ...