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Skin sensitivity testing : a biophysical approach
(2002-04-12)
The skin is regarded as the largest organ of the body, although it is only a few millimetres thick; it is also the interface between the environment and the body's vital structures.
Its large surface area is constantly ...
Diagnostic and prognostic studies in Hodgkin's lymphoma with special reference to the elderly
(2002-11-08)
The introduction of modem staging procedures, and developments in both radiotherapy and chemotherapy have significantly contributed to improved response and survival rates in Hodgkin's lymphoma (HL) during the last decades. ...
Neurotoxicity of methylmercury : analysis of molecular mechanisms and behavioral alterations
(2002-04-05)
MethyImercury (MeHg) is a global pollutant that is toxic for the nervous system, especially during development. Contaminated fish is the main route of human exposure. Recent studies have indicated that neurological alterations ...
Subcellular localization and signalling of Brutons tyrosine kinase (Btk)
(2002-11-28)
Brutons tyrosine kinase (Btk) is a non-receptor tyrosine kinase related
to the Src family of kinases. Mutations in various parts of the gene have
been shown to cause X-linked agammaglobulinemia (XLA), a primary
immunodeficiency in humans...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear ...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Microfluidic analysis and parallel confocal detection of single molecules
(2003-09-12)
) was utilized to investigate hydrodynamic pressure driven flow in microchannels with a cross section of 50 x 50 µm2. The flow itself, was detected non-altered or noninvasively, since only tiny (a couple of nanometer in size) dye-molecules were entrained...