Search
Now showing items 1-10 of 160
From data to decision : a case study of controversies in cancer risk assessment
(2002-11-01)
the chlorinated solvent trichloroethylene (CAS no. 79-01-6). The purpose of the present study is to discuss (1) why risk assessors come to different conclusions, (2) how scientific data are used in risk assessment, and (3) how scientific uncertainty is handled...
The rational use of drugs in a population of very old persons
(2002-02-28)
This thesis investigated the use of drugs in a population of very old
persons. The pattems of use, particularly of psychotropic drugs, and its
appropriateness were assessed. Drug use was also assessed according to
dementia ...
Biological correlates of HIV-1 heterosexual transmission
(2003-11-24)
HIV-1 infection is a sexually transmitted disease but HIV transmission efficiency by sexual contacts appears to be highly variable; this is probably due to the influence that several behavioural, clinical and biological factors exert...
Constitutive and TCDD-induced expression of Ah receptor responsive genes with special focus on the brain and pituitary
(2002-12-27)
in the different brain regions and pituitaries, which provided anatomical and biochemical basis for a possible direct action of AHR ligands on these regions. The expression of cytochrome P450 1A1 (CYP1A1) was dramatically increased after TCDD treatment...
Using SNPs to study complex genetic disease : a population and evolutionary genetics perspective
(2004-05-21)
Associating genes to complex genetic diseases has proven more difficult
than anticipated. Many genetic variants contribute small effects towards
an individual's disease predisposition in polygenic diseases, and ...
Individual health, neighborhood characteristics, and allocation of primary health care resources
(2003-08-08)
. In study 3 there was a gradient between the social participation index and CHD. After adjustment for individual characteristics, the risk of CHD for persons with low social participation remained high (hazard ratio = 1.69). In study 4 the CNI...
Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients
(2002-05-24)
. The allele frequency of CYP2D6*10 was 0.51 in this Korean population. The MRs of the CYP2D6*1/*1, *1/*10 and *10/*10 genotype groups were significantly different (p<0.0001; Kruskal-Wallis test). It was confirmed that the CYP2D6*10 allele is the major cause...
On transplantation of fetal ventral mesencephalon with focus on dopaminergic nerve fiber formation
(2002-04-11)
-derived innervation, factors associated with striatal immaturity were applied concomitantly with VM grafting by usage of polymeric bioactive rods. Knockout of the orphan nuclear receptor Nurr1 in mice causes a complete lack of tyrosine hydroxylase (TH...
Modulation of pain by immune factors : a study on interferon-g and its receptor in nociceptive transmission
(2002-02-22)
at the ultrastructural level in the dorsal hom. The results showed that immunoreactivity for the IFN-gammaR was primarily concentrated in postsynaptic densities in the superficial layers (Rexed's laminae 1 and 11) of the dorsal hom, which indicates that IFN-gamma may...
Immunoregulation of experimental autoimmune neurirtis focuses on cell immunity
(2003-02-07)
subtype (CD4+ and CD8+) and B cell in EAN were examined in CD4-/-, CD8-/-, CD4-8-, B cell knockout (µMT) and wild type mice. The clinical sign, T cell response specific to PO1 80-199 and histopathological changes in CD4-/- mice were significantly lower...