Search
Now showing items 1-10 of 173
Studies of VEGF-B and novel PDGFs in tumorigenesis and angiogenesis
(2004-02-06)
novel PDGF family members, PDGF-C and PDGF-D in tumor growth and tumor angiogenesis.
Characterization of the expression pattern of two isoforms of VEGF-B, VEGF-B167 and VEGF-B186 in tissues and cell lines indicate that VEGF-B167 is the predominant...
Estrogen receptor signalling in mammary epithelial cells
(2004-05-21)
-activated transcription factor STAT5.
Furthermore, we found that ER transcriptional activity fluctuated through the differentiation process in HC 11 cells, with efficient estrogen-induced activation of transcription in proliferating cells and a significant decrease...
Glucocorticoids in the development and homeostasis of T lymphocytes
(2002-05-24)
Until recently the fact that glucocorticoids (GCs) play an essential physiological role in regulation of the immune system in health and disease was not fully appreciated. The main aims of this thesis were to investigate ...
Early induced immune responses : regulation of dendritic cell and NK cell functions
(2003-11-14)
The evolution of the advanced vertebrate adaptive immune system has required co-evolution of sophisticated immune regulating systems that determine immune class of cytokines, antibodies as well as effector mechanisms used ...
Role of protein-tyrosine phospatases in insulin and glucagon secretion in pancreatic islets of healthy rats and spontaneously diabetic GK rats
(2004-03-26)
. At 3.3 mM glucose, 0.1-1 mM pV stimulated insulin secretion (p<0.05), while at 16.7 mM glucose 0.01-0.1 mM pV inhibited its secretion (p<0.05). These effects were not mediated by pV modulation of islet glucose metabolism, or by interference with Gi...
Studies on growth hormone regulation of the CYP2C12 gene in rat liver
(2003-01-09)
region and in the 3 untranslated region (UTR). Interestingly, several different STAT5 complexes were formed on the 3UTR element. In addition to full-length STAT5 also carboxy-truncated STAT5 (STAT5beta)- proteins, lacking their transactivating domain...
Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants
(2003-11-24)
in situ hybridization studies were performed. This showed a highly structured expression pattern with the mRNA prominently synthesized in the proximal tubules of the medullary rays. Using bioinformatic tools combined with 5'RACE PCR we found several TXNRD1...
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(2002-08-30)
, consecutively enrolled as out- and
inpatients at the major paediatric hospital in Addis Ababa, Ethiopia.
The first study identifies HIV as a major risk factor for TB. HIV
prevalence among tuberculous children in Addis Ababa was 12.5%, compared
with 1.6% among...
Some determinants of sick leave for respiratory disease : occupation, asthma, obesity, smoking and rehabilitation
(2002-09-20)
to
be an underreported diagnosis, approximately by a factor of three. In the
study of obesity in paper III the prevalence of obesity in asthmatics on
sick leave was 20.7%, compared with 13.7% in the non-specific pain
patients on sick leave and in 6.5% of a random general...
Esophageal cancer : evaluation of some new strategies
(2002-03-15)
of the 5-fluorouracil dose). These changes made it possible to give the planned treatment to a gradually higher proportion of the patients. No correlations were found between the expressions of p53, bcl-2 or DNA ploidy and tumor response to chemoradiation...