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Sarcoidosis : inflammatory mechanisms and markers of activity
(2002-10-25)
Sarcoidosis is a disease characterized by an accumulation of CD4+ T-lymphocytes in affected organs. Previous findings of an association between the HLA-allele DR17 and an accumulation in bronchoalveolar lavage fluid (BALF) of CD4+ T...
Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides
(2003-05-23)
The signal transduction processes by which an individual cell is able to recognize and respond to its external environment are critical to determining its survival as well as that of the entire organism. In the current ...
Toxin production in clostridium difficile
(2004-05-20)
Clostridium difficile is a is a Gram potential human pathogen. It causing symptoms ranging from mild C. difficile associated diarrhea (CDAD) to severe inflammation of the colon including pseudomembranous colitis and fulminant ...
Immunogenetic studies of multiple sclerosis
(2001-08-31)
are required for T cell activation - an antigen specific mediated by human leukocyte antigens (HLA)/T cell receptor and co-stimulation signal mediated by B7/CD28 and CTLA-4. By using a newly developed PCR-amplification with sequence-specific primers (PCR...
Localization and characterization of genes involved in parathyroid tumor development
(2003-03-21)
The overall goal of this thesis has been to identify new genes and characterize them regarding the involvement in parathyroid tumor development. The parathyroid glands are responsible for the control of calcium homeostasis. ...
Effects of anabolic hormone treatment in elderly patients with hip fracture
(2001-11-15)
after 6 and 12 months.
A double-blind placebo-controlled 12-week study with s.c. daily injections of GH or placebo for 3-4 weeks was performed, on 20 women and men with hip fractures. GH treatment increased the IGF-I levels. The GH treatment had...
Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers
(2002-08-16)
characteristic of a heavily glycosylated protein. Following coexpression of the porcine alpha1,3 galactosyltransferase, the mucin/Ig stained strongly with the alpha-Gal specific lectin Griffonia simplicifolia 1 IB4 in Western blot experiments. The carbohydrate...
Cytomegalovirus after allogeneic haematopoietic stem cell transplantation : complications in the era of CMV-specific antiviral treatment
(2003-12-26)
-disease before day 100 after SCT has
decreased to 4-6%. The cost is an over-treatment with antiviral compounds
and the development of new types of problems. These studies were
undertaken to describe how the modern treatment modalities have changed
the pattern...
Clinical and genetic investigation of hypochondroplasia and dyschondrosteosis
(2001-09-07)
Linear body growth is a multifactorial trait influenced by many environmental and intrinsic factors. Among the intrinsic determinants of body height, genetic and endocrine factors are considered to be the most important. ...
Neurotoxicity of methylmercury : analysis of molecular mechanisms and behavioral alterations
(2002-04-05)
MethyImercury (MeHg) is a global pollutant that is toxic for the nervous system, especially during development. Contaminated fish is the main route of human exposure. Recent studies have indicated that neurological alterations ...