Search
Now showing items 1-10 of 187
O6-methylguanine-DNA-methyltransferase and DNA mismatch repair in relation to drug resistance in malignant melanoma
(2004-03-26)
, MGMT expression levels seem to be more relevant for response to chemotherapy than these MGMT SNPs. We performed a functional analysis by in vitro mutagenesis in E. coli to investigate whether the MGMT I143V or I143V/K178R variants have an effect on MGMT...
A functional genomics approach to study prostate disorders
(2003-09-12)
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized ...
Mortality and cancer incidence following cerebral angiography with thorotrast
(2002-08-30)
).
Patients exposed to Thorotrast had a significant three-fold increase in overall mortality compared to the general population (standardized mortality ratio=SMR 2.8), with similar excesses for men and women. The largest risks were observed for deaths from...
An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors
(2003-01-03)
key findings were elevated risks of EOC among ever users compared with never users of both unopposed estrogens (OR= 1.43, 95% Cl 1.02-2.00), and estrogens supplemented with sequential progestins (OR=1.54, 95% Cl 1.15-2.05), while no excess risk...
A reason to be bitter : cassava classification from the farmers' perspective
(2001-11-16)
" cultivars 153 mg (Cl 143 - 163, range 22 -
661). Farmers' distinction of "bitter" and "cool" cultivars predicts
glucoside levels (r = 0.56). Taste scoring for bitterness by the taste
panel was strongly correlated (r = 0.87) with cyanogenic glucoside levels...
Epidemiological studies of stillbirth and early neonatal death
(2002-02-15)
The aim of this thesis was to investigate risk factors for stillbirth and early neonatal death. The associations between matemal weight, weight gain during pregnancy, hemoglobin concentration, socioeconomic status and ...
Modulation of bile acid and cholesterol metabolism in health and disease
(2004-05-07)
An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis ...
Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice
(2002-02-08)
Neuronal nicotinic acetylcholine receptors (nAChRs) are transmitter-gated ion channel receptors which are widely distributed in the brain. They mediate the effects of several neurotransmitters including ACh, DA, 5-HT and ...
Endoscopic methods for detecting malignancy in patients with ulcerative colitis and primary sclerosing cholangitis
(2002-11-29)
, the cellular DNA content by flow cytometry, and the tumor markers CEA and CA 19-9 in bile and serum.
Materials and Methods: Two series of patients were studied. The first series consisted of 143 patients with extensive UC, observed in a 20 years prospective...
Experimental studies on the role of the gastrointestinal microflora in postsurgical adhesion formation
(2002-05-16)
Introduction: Adhesions occurring after any kind of surgery is a common phenomenon and cause a great deal of morbidity and mortality, incurring a considerable burden on health care systems. Adhesions are especially prominent ...