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Organohalogen contaminants in humans with emphasis on polybrominated diphenyl ethers
(2002-02-08)
. The PCB congener profile was similar in all samples. 2,2',4,4',5,5'-hexaCB (CB-153), 2,2',3,4,4',5'-hexaCB (CB-138) and 2,2',3,4,4',5,5'-heptaCB (CB-180) were the dominant congeners.
OH-PCBs constituted 30-50% of the sum of PCBs in blood samples, 1...
Structural studies of bacterial carbohydrate antigens with focus on oral commensal bacteria
(2002-08-15)
of Streptococcus mitis strains SK137, SK140, and SK598,
which are all part of the normal bacterial flora in the oral cavity.
Structural similarities between these polysaccharides and the
corresponding polysaccharides of the pathogenic Streptococcus pneumoniae
have...
Molecular mechanisms in amyloid fibril formation
(2004-05-21)
P-peptide (Abeta) is suggested to be responsible for Alzheimer's disease. The aggregation profile of Abeta(1-40) studied by electrospray ionisation (ESI) -MS, shows first order kinetics of Abetaaggregation. During the experiment, acid...
Diet and the metabolic syndrome : a cross-sectional study of 301 men from Stockholm County
(2003-11-25)
indicate that underreporters can both weaken associations and also introduce misleading associations. The relative content of the fatty acids 14:0, 15:0 and 17:0 in serum-phospholipids and adipose tissue were related to the intake of dairy fat but also...
Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells
(2003-05-16)
of this thesis, additional modes of LPS/TLR4 induced activation of NF-kappaB in epithelial cells are explored. A potentially novel signalling pathway involving the activation of Akt kinase through p38 MAPK, and thus independent of PI3-kinase, is described...
Characterization and expression of subtypes of nicotinic receptors in brain and adrenal medulla : with focus on development, Alzheimer's disease and transgenic animal models
(2003-08-22)
The cholinergic nicotinic receptors (nAChRs) seem to play an important role in numerous important physiological processes in brain as well as peripheral tissues of man. In first trimester human brain mRNA levels for the alpha3, alpha4, alpha5, alpha...
Rectal cancer : staging, radiotherapy and surgery
(2003-05-02)
In Sweden, about 1800 patients are annually diagnosed with adenocarcinoma of the rectum. Surgery remains the major primary treatment. Adjuvant radiotherapy and total mesorectal excision (TME) are two major achievements in ...
Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice
(2002-02-08)
mice revealed impairment in locomotion at 3 months, and impaired performance in water T-maze spatial working memory tasks at 10 months. Significant increases in alpha-7 nAChRs were observed at 4 months in various brain regions of APPSWE mice, preceding...
Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers
(2002-08-16)
by complement, activated by naturally occuring antibodies in man binding the Galalpha1,3Gal (cc-Gal) carbohydrate epitope on pig tissues. Although cellular xenografts are not lost in a HAR, antibodies have been shown to decrease graft survival in pig to mouse...
The relation of blood pressure to dementia in the elderly : a community-based longitudinal study
(2004-01-09)
Hg) or low diastolic
BP (<65 vs. 66-90 mm Hg) had an increased risk for AD and dementia. The
association between low diastolic BP and high risk of dementia was
particularly pronounced among the users of antihypertensive drugs.
Systolic BP <140 mm Hg...