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Crystallographic studies of gluconate kinase
(2001-11-23)
40-61), the LID (residues 123-130) and the CORE domain (residues 1-39, 62-122, 131-175). The structure of gluconate kinase belongs to the structural family of nucleoside monophosphate (NMP) kinases. In all space groups there is one common dimer...
Description and prediction of clinical radiosensitivity : emphasis on normal tissue reactions
(2004-02-27)
for
external RT. The median follow-up was 19 months. Seventeen of 264
evaluable patients (6%) developed clinical hypothyroidism (increased
TSH/decreased FT4) whereas chemical hypothyroidism (increased TSH/normal
FT4) developed in 57 patients (22%). At 3 years...
Histochemical, biochemical and electrophysiological studies on dorsal root ganglion cultures : focusing on galanin, neuropeptide Y and glutamate
(2001-11-15)
Galanin (Gal) and neuropeptide Y (NPY) are two peptides, which are
strongly up- regulated in a population of dorsal root ganglion (DRG)
neurons after peripheral nerve injury (axotomy). Both peptides may be
involved in ...
Skin sensitivity testing : a biophysical approach
(2002-04-12)
and visual evaluation.
In paper I, sodium lauryl sulphate solutions (SLS) (0.1-5.0%) and a blank were applied to the skin of 10 healthy volunteers.
In paper II, readings were taken from ten regions over the body in 131 healthy volunteers, divided...
Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide
(2003-03-07)
In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes ...
Cognitive functioning in aging and dementia : the role of psychiatric and somatic factors
(2002-05-24)
This doctorial thesis concerns the role of psychiatric and somatic factors in aging and dementia. Five studies are included, all based on data from the Kungsholmen Project, a population-based longitudinal study of aging ...
Parasite signalling and host responses in experimental and human African trypanosomiasis
(2002-08-08)
African trypanosomiasis or sleeping sickness is a disease of tropical Africa caused by the unicellular-flagellated protozoan parasite, Trypanosoma brucei (T b.), which is transmitted by its insect vector, the tsetse fly. ...
Muscarinic M1 and M4 receptor subtypes in normal and pathological conditions in the central nervous system : studies on human and animal tissues using subtype selective ligands
(2003-08-20)
Snake venoms from different mamba species contain toxins that bind to muscarinic acetylcholine receptors (mAChR). The toxins MT-1 (selective for M1 after iodination), M1 toxin-1 (also known as MT7, selective for MI) and M4 toxin-1 (also known as MT3...
Atherosclerosis of the ascending aorta as a risk factor for stroke after cardiac surgery : a study based on epiaortic ultrasound
(2004-04-23)
patient-years.
Results: 26% of the patients had AAA and in 44.4% of them more than one
of 12 possible segments was involved. AAA was found to be the most
important predictive factor for postoperative stroke. The incidence of
stroke was 1.8% in patients...
Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology
(2002-01-25)
enzyme variant originates from the CYP2C9*1 allele, whereas CYP2C9*2 and CYP2C9*3 code for enzymes with amino acid substitutions R144C and 1359L, respectively. There is accumulating evidence that this genetic polymorphism give rise to clinically important...