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Characterisation of eosinophil activity markers : relation to allergic inflammation and apoptosis
(2002-02-15)
as anticoagulant is preferable to EDTA. These studies were designed to allow detection of eosinophil activity markers, both in vitro (the intracellular expression of the EG2-epitope on ECP (EG2), ECP release as well as CD69 expression) and in vivo (eosinophil...
Beta-chemokine and CD8+ T-cell noncytotoxic anti-HIV/SIV activity
(2003-11-07)
in protection against HIV/SIV infection and to disease progression in macaques and also in HIV-2 infected humans.
We showed that the protected and partially protected animals presented in this thesis had higher CD8+ T cell non-cytolytic antiviral response...
Constitutive and TCDD-induced expression of Ah receptor responsive genes with special focus on the brain and pituitary
(2002-12-27)
The 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and related substances are ubiquitous environmental pollutants causing a number of pathological alterations, the most severe being progressive anorexia and body weight loss. The effects on body...
Puumala hantavirus : immune responses and vaccines
(2002-05-10)
antigens immobilized by monoclonal antibodies (MAbs) was shown to be a suitable method to obtain glycoprotein 2 (G2)-specific PUUV neutralizing recombinant Fab fragments. A new epitope, designated G2a3, partially overlapping the neutralizing epitope...
Genetic studies of atopic dermatitis
(2001-11-22)
, using a non- parametric affected relative pair method. In the analysis 109 pedigrees were included, forming 193 affected full-sib pairs and 9 affected half-sib pairs (470 individuals). We also studied linkage and association to six chromosomal regions (2...
Immunopathogenesis of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradoculoneuropathy
(2002-11-15)
have addressed the balance between Th1 and Th2 cytokines over the course of GBS. GBS, but not CIDP, is associated with anti-GM1 and anti-GD1a anti-ganglioside serum antibodies (abs), but the temporal profile of anti-ganglioside abs over the course...
Analyses of the expression and function of the aspartic protease napsin
(2004-04-02)
Two-dimensional gel electrophoresis (2 DE) is one of the powerful tools for the expression profiling of proteins. Using 2 DE, two polypeptides which are expressed exclusively in primary lung adenocarcinomas have been described. Mass spectrometry...
Gene mapping of atopic dermatitis
(2001-11-14)
with atopic dermatitis were tested for linkage to genetic markers in seven candidate chromosome regions (2q35, 5q31-33, 6p21, 11q13, 14q11, 16p12 and Xp11). The region on 14q11 showed evidence in favour of linkage, but not association to the phenotype AD (NPL...
Monitoring pregnancy for improved perinatal outcome in Mozambique
(2002-11-27)
). Mathematically, by using the linear function for optimal adjustment of the enhancement of sensitivity, the latter was improved to 70 % with specificity of 59 % and sum 129 %. It may be argued that this formula has mere academic interest. It shows however...
Disruption of vitamin A metabolism by dioxin
(2003-11-27)
clearance of retinoids. This work aimed at studying mechanisms and consequences of dioxin-induced retinoid disruption in vivo. As model compound we used 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and as model species adult male Sprague-Dawley rats and young...