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Pathogenetic studies of adjuvant-induced arthritis
(2002-11-15)
Rheumatoid arthritis (RA) is a disabling chronic inflammatory disease, presumably autoimmune, that progressively destroys peripheral joints. The etiopathogenesis remains largely unknown, and an understanding of disease ...
Gene regulation by nuclear hormone receptors in vivo
(2003-11-14)
The nuclear hormone receptor superfamily contains 49 different members, including those for thyroid hormone, TRα and TRβ. These receptors are ligand-modulated transcription factors that activate or repress gene activity. ...
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(2002-08-30)
, consecutively enrolled as out- and
inpatients at the major paediatric hospital in Addis Ababa, Ethiopia.
The first study identifies HIV as a major risk factor for TB. HIV
prevalence among tuberculous children in Addis Ababa was 12.5%, compared
with 1.6% among...
Molecular epidemiology of hepatitis A and hepatitis B virus in central America
(2002-04-17)
, classified as genotype D based on their S gene sequences, although encoding d-specificity. The two strains were confirmed to belong to genotype D, and differed from other genotype D strains by 2.8-4.6%. However, their S genes encoded Lys 122, Thr 127 and Arg...
Candidate genes and the dopamine system : possible implications in complex neurological and psychiatric disease
(2002-04-23)
The mesencephalic dopamine (DA) system is strongly involved in the pathogenesis of Parkinsons disease (PD), where symptoms occur after the loss of the vast majority of DA neurons. An involvement of this system also in ...
Trinucleotide repeats and neuropsychiatric phenotypes
(2001-11-02)
loci. CTG18.1 expansions were more frequently seen in patients as compared to healthy individuals (odds ratio 2.6-2.8), and their size correlated inversely with age-of-onset. The allele distribution at ERDA1 was not significantly different between...
The role of Malassezia in the pathogenesis of atopic eczema/dermatitis syndrome
(2002-01-25)
restricted allergens.
To study the occurrence of reactivity to Malassezia extract and three
recombinant Malassezia allergens (rMal s 1, rMal s 5 and rMal s 6),
measured as specific serum IgE, positive skin prick test (SPT) and atopy
patch test (APT...
Studies on immunological mechanisms of induced arthritis in the rat
(2002-11-22)
Experimental arthritis induced with adjuvants shares many features with
the human autoimmune disorder rheumatoid arthritis (RA). The use of
arthritis models is therefore a relevant approach in the search for
pathogenic ...
New approaches for treatment of acute intermittent porphyria by enzyme substitution and gene therapy : evaluation in vitro and in vivo
(2004-05-07)
the
level found in control cells the protoporphyrin synthesis increased to
127-152 % of normal, showing that the biochemical defect could be
corrected. Similar results were obtained in mouse PBGD-deficient cells.
Before starting the in vivo trials, the AIP...
On the role of HMGB1 and IL-1 in tissue barrier defense
(2001-11-30)
within the immune system. Today more than 100 cytokines have been reported including the proinflammatory cytokines, e.g., interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor- alpha (TNF-alpha), as an important subgroup. Antimicrobial...