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Crystallographic studies of gluconate kinase
(2001-11-23)
40-61), the LID (residues 123-130) and the CORE domain (residues 1-39, 62-122, 131-175). The structure of gluconate kinase belongs to the structural family of nucleoside monophosphate (NMP) kinases. In all space groups there is one common dimer...
The role of galanin in chronic pain mechanisms
(2002-11-29)
The general aim of these studies is to further elucidate the role of
galanin in pain mechanisms. We have utilized normal and genetically
modified animals and a variety of techniques. In order to use genetically
modified ...
The central role of the CD4 T-helper cell in HIV infection : analysis of cell mediated responses and CCR-5 genotypes in HIV-1 infected individuals
(2001-10-26)
, certain chemokine receptors have been
identified as coreceptors for the cellular entry of HIV. The main
coreceptor CCR-5 is used by most primary viral isolates (NSI). A switch
in coreceptor usage to the CXCR-4 receptor phenotype (SI) is associated...
Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
(2003-02-14)
2C19, CYP2C9, CYP1B1, CYP1A2 and XO, with special emphasis on the Ethiopian population. Two different Ethiopian populations were investigated, healthy unrelated subjects living in Ethiopia (n=122) and Ethiopians living in Sweden (n=73). In the first...
Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1
(2004-01-30)
Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by
altering neuronal signal transduction pathways, by increasing AP
production or by triggering a number of proapoptotic mechanisms. The
present ...
Apolipoprotein E and Alzheimer's diseases : signals and effects
(2002-04-26)
was shown to be modulated by adenosine 3':5'-cyclic monophosphate (cAMP) and factors that regulate intracellular cAMP. Retinoic acid potentiated, while the protein kinase C (PKC) activator phorbol 12- myristate 13-acetate (PMA) reversed the cAMP mediated...
Molecular epidemiology of hepatitis A and hepatitis B virus in central America
(2002-04-17)
parts of the world.
Molecular typing of HAV was performed by sequence analysis of the 5'-end of the VP1 region. HAV strains from CA were found to belong to genotype 1A. The strains were mostly similar to each other, and unrelated to subtype 1 A...
Pain following spinal cord injury
(2004-10-01)
I encompassed 456 individuals with an SCI, which was 76.5% of the total prevalence population in the greater Stockholm area. In paper II, 65 women were matched with 65 men regarding age, ASIA impairment grade, and level of lesion. These patients were...
Osäkra 'sjukdomar' – dilemman och möjligheter : kvinnliga 'patienters' och läkares erfarenheter av kroniskt trötthetssyndrom och fibromyalgi
(2003-08-08)
This thesis focuses on women with chronic fatigue syndrome (M) and fibromyalgia and how they depict their illness experience. Physicians' experiences of these patient groups have also been examined. This thesis is appropriated ...
Spinal cord injury : mechanical and molecular aspects
(2002-05-10)
Traumatic spinal cord injury leads to full or partial paralysis and loss
of sensation below the level of injury. The annual incidence of spinal
cord injury in the United States is 3-5 per 100,000 and in Sweden is
1.5-2 per 100,000. This translates...